Severe bone marrow suppression and hepatic dysfunction caused by piperacillin/tazobactam

Scand J Infect Dis. 2013 Nov;45(11):885-7. doi: 10.3109/00365548.2013.805426. Epub 2013 Jul 5.

Abstract

Piperacillin/tazobactam (TZP) is a commonly prescribed antibiotic. Here, we report a patient who developed agranulocytosis, thrombocytopenia, and severe hepatic dysfunction on day 17 while receiving TZP treatment for an intracranial infection. Bone marrow suppression and hepatic dysfunction are serious adverse effects that should be kept in mind when using long-term TZP.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Agranulocytosis / chemically induced*
  • Bone Marrow / drug effects*
  • Humans
  • Liver / drug effects*
  • Liver Diseases*
  • Male
  • Penicillanic Acid / administration & dosage
  • Penicillanic Acid / adverse effects
  • Penicillanic Acid / analogs & derivatives*
  • Piperacillin / administration & dosage
  • Piperacillin / adverse effects
  • Piperacillin, Tazobactam Drug Combination
  • Thrombocytopenia / chemically induced*

Substances

  • Piperacillin, Tazobactam Drug Combination
  • Penicillanic Acid
  • Piperacillin