Piperacillin/tazobactam-induced neutropenia, thrombocytopenia, and fever during treatment of a diabetic foot infection

Scand J Infect Dis. 2013 Jan;45(1):73-6. doi: 10.3109/00365548.2012.697638. Epub 2012 Jul 1.

Abstract

Piperacillin/tazobactam (PTZ) is frequently used in patients with diabetic foot infections. Herein, we report a patient who developed severe neutropenia, thrombocytopenia, and fever while receiving PTZ for a diabetic foot infection. We recommend vigilance when long-term PTZ use is planned in patients with diabetic foot infections.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Bacterial Agents / adverse effects*
  • Anti-Bacterial Agents / therapeutic use
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetic Foot / blood*
  • Diabetic Foot / drug therapy
  • Diabetic Foot / surgery
  • Fever / blood
  • Fever / chemically induced*
  • Humans
  • Male
  • Neutropenia / chemically induced*
  • Penicillanic Acid / adverse effects
  • Penicillanic Acid / analogs & derivatives
  • Penicillanic Acid / therapeutic use
  • Piperacillin / adverse effects
  • Piperacillin / therapeutic use
  • Piperacillin, Tazobactam Drug Combination
  • Thrombocytopenia / chemically induced*

Substances

  • Anti-Bacterial Agents
  • Piperacillin, Tazobactam Drug Combination
  • Penicillanic Acid
  • Piperacillin