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Medline ® Abstract for Reference 41

of 'Pertussis infection in infants and children: Clinical features and diagnosis'

Epidemiological features of pertussis in hospitalized patients in Canada, 1991-1997: report of the Immunization Monitoring Program--Active (IMPACT).
Halperin SA, Wang EE, Law B, Mills E, Morris R, Déry P, Lebel M, MacDonald N, Jadavji T, Vaudry W, Scheifele D, Delage G, Duclos P
Clin Infect Dis. 1999;28(6):1238.
To assess the morbidity associated with the continued high levels of pertussis, we studied all children<2 years of age who were admitted to the 11 Immunization Monitoring Program--Active (IMPACT) centers, which constitute 85% of Canada's tertiary care pediatric beds. In the 7 years preceding implementation of acellular pertussis vaccine, a total of 1,082 pertussis cases were reported, of which 49.1% were culture-confirmed. The median age of the patients was 12.4 weeks; 78.9% of cases were in children<6 months of age. Complications of pertussis were common: pneumonia was reported in 9.4% of cases, new seizures in 2.3%, and encephalopathy in 0.5%. There were 10 deaths (0.9%), all in children<or =6 months of age. Duration of hospitalization was longer (9.3 days vs. 4.9 days; P = .001) and intensive care was required more frequently (19.2% vs. 4.9%; P = .001) in infants under<6 months of age than in those>or =6 months. Pertussis continues to cause significant morbidity and occasional mortality in Canada, particularly in young infants.
Department of Pediatrics, Dalhousie University, IWK Grace Health Centre, Halifax, Nova Scotia, Canada. shalperin@iwkgrace.ns.ca