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Penicillin skin testing

Roland Solensky, MD
Section Editor
N Franklin Adkinson, Jr, MD
Deputy Editor
Anna M Feldweg, MD


Penicillin skin testing is a tool used in the diagnosis of penicillin allergy. This topic will review the indications, safety, protocols, and interpretation of skin testing with penicillin and the aminopenicillins (amoxicillin and ampicillin).

An overview of allergy skin testing (for various types of allergens), a general discussion of the diagnosis of drug allergy, and the clinical manifestations of penicillin allergy, are discussed separately. (See "Overview of skin testing for allergic disease" and "An approach to the patient with drug allergy" and "Penicillin allergy: Immediate reactions".)


Penicillins include the following:

The natural penicillins – Penicillin V (oral), penicillin G (parenteral), benzathine penicillin (intramuscular), and procaine penicillin (intramuscular)

The antistaphylococcal penicillins – Dicloxacillin, nafcillin, oxacillin, and cloxacillin

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Literature review current through: Nov 2017. | This topic last updated: Jun 26, 2017.
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