Pathophysiology of the trigeminal autonomic cephalalgias
- Arne May, MD
Arne May, MD
- Professor of Neurology, Department of Systems Neuroscience
- University Clinic Hamburg, Eppendorf (UKE)
- Anna S Cohen, MD
Anna S Cohen, MD
- Consultant Neurologist
- Royal Free Hospital, London
- Peter J Goadsby, MD, PhD
Peter J Goadsby, MD, PhD
- Professor of Neurology
- King's College London
- University of California, San Francisco
The trigeminal autonomic cephalalgias (TACs) are a group of primary headache disorders characterized by unilateral trigeminal distribution pain that occurs in association with prominent ipsilateral cranial autonomic features [1,2]. The TACs include cluster headache, paroxysmal hemicrania, short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT), short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA), and hemicrania continua .
Despite their common elements, the TACs differ in attack duration and frequency, as well as the response to therapy (table 1).
●Cluster headache has the longest attack duration (minutes to hours) and relatively low attack frequency (up to eight a day)
●Paroxysmal hemicrania has intermediate duration (minutes) and intermediate attack frequency (up to 40 a day)
●SUNCT/SUNA has the shortest attack duration (seconds to minutes) and the highest attack frequency (up to 200 a day)To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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