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Medline ® Abstract for Reference 69

of 'Pathophysiology of and immune response to Helicobacter pylori infection'

69
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Cytokine gene expression in Helicobacter pylori associated antral gastritis.
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Moss SF, Legon S, Davies J, Calam J
SO
Gut. 1994;35(11):1567.
 
Infection of the gastric antrum by Helicobacter pylori is characterised by a cellular inflammatory infiltrate. Whether cytokines are involved in the pathogenesis of this gastritis has been investigated by studying the effect of eradicating H pylori on the expression of genes encoding the cytokines interleukin 8 (IL-8) and tumour necrosis factor alpha (TNF-alpha) in the antral mucosa. Gastric antral biopsy specimens were taken from nine patients with duodenal ulcers and cytokine transcripts were identified and quantified by northern blotting. After H pylori had been eradicated the chronic inflammatory infiltrate decreased in all the patients and the polymorphonuclear infiltrate virtually disappeared. Expression of genes also decreased. After eradication, the median TNF-alpha mRNA/rRNA fell to 48% (p = 0.02) and the median IL-8 mRNA/rRNA fell to 5% (p = 0.004) of initial values. These results support the role of increased synthesis of these cytokines in the pathogenesis of the gastritis.
AD
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London.
PMID