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Medline ® Abstract for Reference 1

of 'Pathology, classification, and grading of neuroendocrine tumors arising in the digestive system'

The epidemiology of gastroenteropancreatic neuroendocrine tumors.
Lawrence B, Gustafsson BI, Chan A, Svejda B, Kidd M, Modlin IM
Endocrinol Metab Clin North Am. 2011;40(1):1.
In this article, updated analyses of the National Cancer Institute Surveillance, Epidemiology and End Results (SEER) registry (1973-2007) are presented and compared with epidemiologic GEP-NET data from Europe and Asia. Several studies have demonstrated a steadily increasing incidence of GEP-NETs, and this escalation is still ongoing (SEER data 2004-2007). The common primary GEP-NET sites exhibit unique epidemiologic profiles with distinct patterns of incidence, age at diagnosis, stage, and survival. Overall, GEP-NET survival has improved over the past 3 decades, although the outcome for poorly differentiated tumors remains dismal.
Gastrointestinal Pathobiology Research Group, Department of Surgery, Yale University School of Medicine, 310 Cedar Street, PO Box 208602, New Haven, CT 06520-8062, USA.