Medline ® Abstract for Reference 38
of 'Pathogenesis of Sjögren's syndrome'
Autoimmunity and coxsackievirus infection in primary Sjogren's syndrome.
Triantafyllopoulou A, Moutsopoulos HM
Ann N Y Acad Sci. 2005;1050:389.
Exocrine gland epithelial cells are the target of autoimmune pathology in primary Sjögren's syndrome (pSS). Their activated phenotype has incited the notion that they are infected by a virus. We recently presented evidence that coxsackieviruses may persistently infect the salivary glands of pSS patients. We hypothesize that coxsackieviruses may play a permissive role for the perpetuation and possibly the induction of autoimmune disease in pSS.
Department of Pathophysiology, National University of Athens Medical School, M. Asias 75, Goudi, Athens 11527, Greece.