Pathogenesis of metabolic alkalosis
- Michael Emmett, MD
Michael Emmett, MD
- Editor-in-Chief — Nephrology
- Section Editor — Fluid and Electrolytes
- Chief of Internal Medicine
- Baylor University Medical Center
- Harold Szerlip, MD, FACP, FCCP, FASN, FNKF
Harold Szerlip, MD, FACP, FCCP, FASN, FNKF
- Director, Nephrology Division, Baylor University Medical Center, Dallas
- Program Director, Nephrology Training Program, Baylor University Medical Center
- Clinical Professor of Medicine, Texas A&M College of Medicine
- Adjunct Professor of Medicine, Texas College of Osteopathic Medicine
Metabolic alkalosis is a relatively common disorder that is most often generated by diuretic therapy or the loss of gastric secretions due to vomiting (which may be surreptitious) or nasogastric suction. Metabolic alkalosis may also result from severe hypokalemia, alkali ingestion when renal function is markedly diminished, primary aldosteronism, or disorders that mimic primary aldosteronism.
The pathogenesis of metabolic alkalosis will be reviewed here. The causes, evaluation, and treatment of this disorder are discussed separately. (See "Causes of metabolic alkalosis" and "Clinical manifestations and evaluation of metabolic alkalosis" and "Treatment of metabolic alkalosis".)
The development of metabolic alkalosis and its subsequent maintenance generally have distinct and separate explanations [1-3]:
●An elevation in the plasma bicarbonate concentration can develop due to excessive hydrogen ion loss in the urine or gastrointestinal tract, hydrogen ion movement into the cells, the administration of bicarbonate salts (or other alkalinizing salts such as sodium acetate or lactate), or volume contraction around a relatively constant amount of extracellular bicarbonate (called a contraction alkalosis). (See "Causes of metabolic alkalosis".)
●An elevated bicarbonate concentration is maintained by conditions that reduce bicarbonate filtration, enhance bicarbonate reabsorption, or impair bicarbonate secretion, and thereby prevent rapid excretion of the excess bicarbonate in the urine. Rapid bicarbonate excretion would otherwise correct the alkalosis [1,4].To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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