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Pathogenesis of Behçet's syndrome

Ellison L Smith, MD
Yusuf Yazici, MD
Section Editor
Peter A Merkel, MD, MPH
Deputy Editor
Monica Ramirez Curtis, MD, MPH


Behçet's syndrome is an inflammatory disease characterized by recurrent oral aphthous ulcers and numerous potential systemic manifestations. These include genital ulcers; skin lesions; and ocular, neurologic, vascular, articular, and gastrointestinal disease.

Many, but not all, clinical manifestations of Behçet's syndrome are believed to be due to vasculitis. Among the systemic vasculitides, Behçet's syndrome is remarkable for its ability to involve blood vessels of all sizes (small, medium, and large) on both the arterial and venous sides of the circulation.

The etiology and pathogenesis of Behçet's syndrome are discussed in this review. The clinical manifestations, diagnosis, and treatment of this disorder are presented separately. (See "Clinical manifestations and diagnosis of Behçet's syndrome" and "Treatment of Behçet’s syndrome".)


Behçet's syndrome is more common (and often more severe) along the ancient silk road, which extends from eastern Asia to the Mediterranean [1]. It is most common in Turkey (80 to 370 cases per 100,000), while the prevalence ranges from 13.5 to 20 per 100,000 in Japan, Korea, China, Iran, and Saudi Arabia [1]. Prevalence in Paris, France in 2003 was 7.1 per 100,000, with rates of 2.4 per 100,000 in those of European ancestry, of 34.6 per 100,000 in those of North African ancestry, and of 17.5 per 100,000 in those of Asian ancestry [2,3]. Estimates of prevalence in the United States and Europe have ranged from 0.12 to 7.5 per 100,000. Analysis of residents of Olmsted County, Minnesota over a 45-year period identified a prevalence of 5.2 per 100,000 [4]. It is somewhat more common in men in the eastern Mediterranean area and in women in north European countries, and it typically affects young adults 20 to 40 years of age [1]. Immigrant and refugee populations from areas of high Behçet's prevalence demonstrate increased risk of disease development [5].


The underlying cause of Behçet's syndrome is unknown. As with other autoimmune diseases, the disorder may represent aberrant immune activity triggered by exposure to an agent, perhaps infectious, in patients with a genetic predisposition to develop the disease. Major disease mechanisms in Behçet's syndrome include the following [6]:

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Literature review current through: Sep 2017. | This topic last updated: Oct 06, 2017.
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  1. Sakane T, Takeno M, Suzuki N, Inaba G. Behçet's disease. N Engl J Med 1999; 341:1284.
  2. Mahr A, Belarbi L, Wechsler B, et al. Population-based prevalence study of Behçet's disease: differences by ethnic origin and low variation by age at immigration. Arthritis Rheum 2008; 58:3951.
  3. Yazici H, Seyahi E, Yurdakul S. Behçet's syndrome is not so rare: why do we need to know? Arthritis Rheum 2008; 58:3640.
  4. Calamia KT, Wilson FC, Icen M, et al. Epidemiology and clinical characteristics of Behçet's disease in the US: a population-based study. Arthritis Rheum 2009; 61:600.
  5. Mahr A, Maldini C. [Epidemiology of Behçet's disease]. Rev Med Interne 2014; 35:81.
  6. Direskeneli H. Behçet's disease: infectious aetiology, new autoantigens, and HLA-B51. Ann Rheum Dis 2001; 60:996.
  7. de Menthon M, Lavalley MP, Maldini C, et al. HLA-B51/B5 and the risk of Behçet's disease: a systematic review and meta-analysis of case-control genetic association studies. Arthritis Rheum 2009; 61:1287.
  8. Arber N, Klein T, Meiner Z, et al. Close association of HLA-B51 and B52 in Israeli patients with Behçet's syndrome. Ann Rheum Dis 1991; 50:351.
  9. Salvarani C, Boiardi L, Mantovani V, et al. Association of MICA alleles and HLA-B51 in Italian patients with Behçet's disease. J Rheumatol 2001; 28:1867.
  10. Kötter I, Günaydin I, Stübiger N, et al. Comparative analysis of the association of HLA-B*51 suballeles with Behçet's disease in patients of German and Turkish origin. Tissue Antigens 2001; 58:166.
  11. Ahmad T, Wallace GR, James T, et al. Mapping the HLA association in Behçet's disease: a role for tumor necrosis factor polymorphisms? Arthritis Rheum 2003; 48:807.
  12. Baskan EB, Yilmaz E, Saricaoglu H, et al. Detection of parvovirus B19 DNA in the lesional skin of patients with Behçet's disease. Clin Exp Dermatol 2007; 32:186.
  13. Mizuki N, Meguro A, Tohnai I, et al. Association of Major Histocompatibility Complex Class I Chain-Related Gene A and HLA-B Alleles with Behçet's Disease in Turkey. Jpn J Ophthalmol 2007; 51:431.
  14. Evereklioglu C. Current concepts in the etiology and treatment of Behçet disease. Surv Ophthalmol 2005; 50:297.
  15. Bennani N, Atouf O, Benseffaj N, et al. [HLA polymorphism and Behçet's disease in Moroccan population]. Pathol Biol (Paris) 2009; 57:403.
  16. Kamiishi T, Itoh Y, Meguro A, et al. [Four-digit allele genotyping of HLA-A and HLA-B genes in Japanese patients with Behçet's disease (BD) by a PCR-SSOP-luminex method and stratification analysis according to each major symptom of BD]. Nippon Ganka Gakkai Zasshi 2008; 112:451.
  17. Meguro A, Inoko H, Ota M, et al. Genetics of Behçet disease inside and outside the MHC. Ann Rheum Dis 2010; 69:747.
  18. Takeuchi M, Kastner DL, Remmers EF. The immunogenetics of Behçet's disease: A comprehensive review. J Autoimmun 2015; 64:137.
  19. Gül A, Hajeer AH, Worthington J, et al. Evidence for linkage of the HLA-B locus in Behçet's disease, obtained using the transmission disequilibrium test. Arthritis Rheum 2001; 44:239.
  20. Sakane T, Takeno M. Novel approaches to Behçet's disease. Expert Opin Investig Drugs 2000; 9:1993.
  21. Ermakova NA, Alekberova ZS, Prokaeva TB, Poljanskaja IB. Frequency of HLA in patients with Behçet's disease and association with occlusive retinal vasculitis. Adv Exp Med Biol 2003; 528:231.
  22. Choukri F, Chakib A, Himmich H, et al. HLA-B phenotype modifies the course of Behçet's disease in Moroccan patients. Tissue Antigens 2003; 61:92.
  23. Gül A, Uyar FA, Inanc M, et al. Lack of association of HLA-B*51 with a severe disease course in Behçet's disease. Rheumatology (Oxford) 2001; 40:668.
  24. Mizuki N, Inoko H, Ohno S. Pathogenic gene responsible for the predisposition of Behçet's disease. Int Rev Immunol 1997; 14:33.
  25. Gebreselassie D, Spiegel H, Vukmanovic S. Sampling of major histocompatibility complex class I-associated peptidome suggests relatively looser global association of HLA-B*5101 with peptides. Hum Immunol 2006; 67:894.
  26. Wildner G, Thurau SR. Cross-reactivity between an HLA-B27-derived peptide and a retinal autoantigen peptide: a clue to major histocompatibility complex association with autoimmune disease. Eur J Immunol 1994; 24:2579.
  27. Ota M, Mizuki N, Katsuyama Y, et al. The critical region for Behçet disease in the human major histocompatibility complex is reduced to a 46-kb segment centromeric of HLA-B, by association analysis using refined microsatellite mapping. Am J Hum Genet 1999; 64:1406.
  28. Muñoz-Saá I, Cambra A, Pallarés L, et al. Allelic diversity and affinity variants of MICA are imbalanced in Spanish patients with Behçet's disease. Scand J Immunol 2006; 64:77.
  29. Hughes EH, Collins RW, Kondeatis E, et al. Associations of major histocompatibility complex class I chain-related molecule polymorphisms with Behcet's disease in Caucasian patients. Tissue Antigens 2005; 66:195.
  30. Gül A, Hajeer AH, Worthington J, et al. Linkage mapping of a novel susceptibility locus for Behçet's disease to chromosome 6p22-23. Arthritis Rheum 2001; 44:2693.
  31. Hughes T, Coit P, Adler A, et al. Identification of multiple independent susceptibility loci in the HLA region in Behçet's disease. Nat Genet 2013; 45:319.
  32. Kirino Y, Bertsias G, Ishigatsubo Y, et al. Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. Nat Genet 2013; 45:202.
  33. Akpolat T, Koç Y, Yeniay I, et al. Familial Behçet's disease. Eur J Med 1992; 1:391.
  34. Koné-Paut I, Geisler I, Wechsler B, et al. Familial aggregation in Behçet's disease: high frequency in siblings and parents of pediatric probands. J Pediatr 1999; 135:89.
  35. Fresko I, Soy M, Hamuryudan V, et al. Genetic anticipation in Behçet's syndrome. Ann Rheum Dis 1998; 57:45.
  36. Mizuki N, Ota M, Kimura M, et al. Triplet repeat polymorphism in the transmembrane region of the MICA gene: a strong association of six GCT repetitions with Behçet disease. Proc Natl Acad Sci U S A 1997; 94:1298.
  37. Wei F, Zhang YU, Li W. A meta-analysis of the association between Behçet's disease and MICA-A6. Biomed Rep 2016; 4:741.
  38. Zhang J, Liao D, Yang L, Hou S. Association between Functional MICA-TM and Behcet's Disease: A Systematic Review and Meta-analysis. Sci Rep 2016; 6:21033.
  39. Lee YH, Song GG. Associations between major histocompatibility complex class I chain-related gene A polymorphisms and susceptibility to Behcet's disease. A meta-analysis. Z Rheumatol 2015; 74:714.
  40. Guasp P, Barnea E, González-Escribano MF, et al. The Behçet's disease-associated variant of the aminopeptidase ERAP1 shapes a low-affinity HLA-B*51 peptidome by differential subpeptidome processing. J Biol Chem 2017; 292:9680.
  41. Guasp P, Alvarez-Navarro C, Gomez-Molina P, et al. The Peptidome of Behçet's Disease-Associated HLA-B*51:01 Includes Two Subpeptidomes Differentially Shaped by Endoplasmic Reticulum Aminopeptidase 1. Arthritis Rheumatol 2016; 68:505.
  42. Salvarani C, Boiardi L, Casali B, et al. Endothelial nitric oxide synthase gene polymorphisms in Behçet's disease. J Rheumatol 2002; 29:535.
  43. Gunesacar R, Erken E, Bozkurt B, et al. Analysis of CD28 and CTLA-4 gene polymorphisms in Turkish patients with Behcet's disease. Int J Immunogenet 2007; 34:45.
  44. Karasneh J, Gül A, Ollier WE, et al. Whole-genome screening for susceptibility genes in multicase families with Behçet's disease. Arthritis Rheum 2005; 52:1836.
  45. Karasneh JA, Hajeer AH, Silman A, et al. Polymorphisms in the endothelial nitric oxide synthase gene are associated with Behçet's disease. Rheumatology (Oxford) 2005; 44:614.
  46. Salvarani C, Boiardi L, Casali B, et al. Vascular endothelial growth factor gene polymorphisms in Behçet's disease. J Rheumatol 2004; 31:1785.
  47. Kim JU, Chang HK, Lee SS, et al. Endothelial nitric oxide synthase gene polymorphisms in Behçet's disease and rheumatic diseases with vasculitis. Ann Rheum Dis 2003; 62:1083.
  48. Verity DH, Wallace GR, Vaughan RW, et al. HLA and tumour necrosis factor (TNF) polymorphisms in ocular Behçet's disease. Tissue Antigens 1999; 54:264.
  49. Lee EB, Kim JY, Lee YJ, et al. TNF and TNF receptor polymorphisms in Korean Behcet's disease patients. Hum Immunol 2003; 64:614.
  50. Kamoun M, Chelbi H, Houman MH, et al. Tumor necrosis factor gene polymorphisms in Tunisian patients with Behcet's disease. Hum Immunol 2007; 68:201.
  51. Nakao K, Isashiki Y, Sonoda S, et al. Nitric oxide synthase and superoxide dismutase gene polymorphisms in Behçet disease. Arch Ophthalmol 2007; 125:246.
  52. Tursen U, Tamer L, Api H, et al. Cytochrome P450 polymorphisms in patients with Behcet's disease. Int J Dermatol 2007; 46:153.
  53. Alayli G, Aydin F, Coban AY, et al. T helper 1 type cytokines polymorphisms: association with susceptibility to Behçet's disease. Clin Rheumatol 2007; 26:1299.
  54. Lee YJ, Kang SW, Park JJ, et al. Interleukin-18 promoter polymorphisms in patients with Behçet's disease. Hum Immunol 2006; 67:812.
  55. Akman A, Sallakci N, Coskun M, et al. TNF-alpha gene 1031 T/C polymorphism in Turkish patients with Behçet's disease. Br J Dermatol 2006; 155:350.
  56. Chmaisse HN, Fakhoury HA, Salti NN, Makki RF. The ICAM-1 469 T/C gene polymorphism but not 241 G/A is associated with Behçets disease in the Lebanese population. Saudi Med J 2006; 27:604.
  57. Fei Y, Webb R, Cobb BL, et al. Identification of novel genetic susceptibility loci for Behçet's disease using a genome-wide association study. Arthritis Res Ther 2009; 11:R66.
  58. Touma Z, Farra C, Hamdan A, et al. TNF polymorphisms in patients with Behçet disease: a meta-analysis. Arch Med Res 2010; 41:142.
  59. Dilek K, Ozçimen AA, Saricaoğlu H, et al. Cytokine gene polymorphisms in Behçet's disease and their association with clinical and laboratory findings. Clin Exp Rheumatol 2009; 27:S73.
  60. Kamoun M, Houman MH, Hamzaoui A, Hamzaoui K. Vascular endothelial growth factor gene polymorphisms and serum levels in Behçet's disease. Tissue Antigens 2008; 72:581.
  61. Park KS, Baek JA, Do JE, et al. CTLA4 gene polymorphisms and soluble CTLA4 protein in Behcet's disease. Tissue Antigens 2009; 74:222.
  62. Horie Y, Meguro A, Ota M, et al. Association of TLR4 polymorphisms with Behcet's disease in a Korean population. Rheumatology (Oxford) 2009; 48:638.
  63. Sousa I, Shahram F, Francisco D, et al. Brief report: association of CCR1, KLRC4, IL12A-AS1, STAT4, and ERAP1 With Behçet's disease in Iranians. Arthritis Rheumatol 2015; 67:2742.
  64. Gül A. Pathogenesis of Behçet's disease: autoinflammatory features and beyond. Semin Immunopathol 2015; 37:413.
  65. Hu J, Hou S, Zhu X, et al. Interleukin-10 gene polymorphisms are associated with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in the Chinese Han population. Mol Vis 2015; 21:589.
  66. Ombrello MJ, Kastner DL, Remmers EF. Endoplasmic reticulum-associated amino-peptidase 1 and rheumatic disease: genetics. Curr Opin Rheumatol 2015; 27:349.
  67. Yalçin B, Atakan N, Dogan S. Association of interleukin-23 receptor gene polymorphism with Behçet disease. Clin Exp Dermatol 2014; 39:881.
  68. Livneh A, Aksentijevich I, Langevitz P, et al. A single mutated MEFV allele in Israeli patients suffering from familial Mediterranean fever and Behçet's disease (FMF-BD). Eur J Hum Genet 2001; 9:191.
  69. Kogan A, Shinar Y, Lidar M, et al. Common MEFV mutations among Jewish ethnic groups in Israel: high frequency of carrier and phenotype III states and absence of a perceptible biological advantage for the carrier state. Am J Med Genet 2001; 102:272.
  70. Rabinovich E, Shinar Y, Leiba M, et al. Common FMF alleles may predispose to development of Behcet's disease with increased risk for venous thrombosis. Scand J Rheumatol 2007; 36:48.
  71. Dursun A, Durakbasi-Dursun HG, Zamani AG, et al. Genetic analysis of MEFV gene pyrin domain in patients with Behçet's disease. Mediators Inflamm 2006; 2006:41783.
  72. Direskeneli H, Hasan A, Shinnick T, et al. Recognition of B-cell epitopes of the 65 kDa HSP in Behçet's disease. Scand J Immunol 1996; 43:464.
  73. de Smet MD, Ramadan A. Circulating antibodies to inducible heat shock protein 70 in patients with uveitis. Ocul Immunol Inflamm 2001; 9:85.
  74. Suzuki Y, Hoshi K, Matsuda T, Mizushima Y. Increased peripheral blood gamma delta+ T cells and natural killer cells in Behçet's disease. J Rheumatol 1992; 19:588.
  75. Skin hypersensitivity to streptococcal antigens and the induction of systemic symptoms by the antigens in Behçet's disease--a multicenter study. The Behcet's Disease Research Committee of Japan. J Rheumatol 1989; 16:506.
  76. Mumcu G, Inanc N, Aydin SZ, et al. Association of salivary S. mutans colonisation and mannose-binding lectin deficiency with gender in Behçet's disease. Clin Exp Rheumatol 2009; 27:S32.
  77. Seoudi N, Bergmeier LA, Drobniewski F, et al. The oral mucosal and salivary microbial community of Behçet's syndrome and recurrent aphthous stomatitis. J Oral Microbiol 2015; 7:27150.
  78. Consolandi C, Turroni S, Emmi G, et al. Behçet's syndrome patients exhibit specific microbiome signature. Autoimmun Rev 2015; 14:269.
  79. Yokota K, Hayashi S, Fujii N, et al. Antibody response to oral streptococci in Behçet's disease. Microbiol Immunol 1992; 36:815.
  80. Isogai E, Ohno S, Kotake S, et al. Chemiluminescence of neutrophils from patients with Behçet's disease and its correlation with an increased proportion of uncommon serotypes of Streptococcus sanguis in the oral flora. Arch Oral Biol 1990; 35:43.
  81. Calgüneri M, Ertenli I, Kiraz S, et al. Effect of prophylactic benzathine penicillin on mucocutaneous symptoms of Behçet's disease. Dermatology 1996; 192:125.
  82. Hirohata S, Oka H, Mizushima Y. Streptococcal-related antigens stimulate production of IL6 and interferon-gamma by T cells from patients with Behcet's disease. Cell Immunol 1992; 140:410.
  83. Mochizuki M, Suzuki N, Takeno M, et al. Fine antigen specificity of human gamma delta T cell lines (V gamma 9+) established by repetitive stimulation with a serotype (KTH-1) of a gram-positive bacterium, Streptococcus sanguis. Eur J Immunol 1994; 24:1536.
  84. Evereklioglu C, Er H, Türköz Y, Cekmen M. Serum levels of TNF-alpha, sIL-2R, IL-6, and IL-8 are increased and associated with elevated lipid peroxidation in patients with Behçet's disease. Mediators Inflamm 2002; 11:87.
  85. Calgüneri M, Kiraz S, Ertenli I, et al. The effect of prophylactic penicillin treatment on the course of arthritis episodes in patients with Behçet's disease. A randomized clinical trial. Arthritis Rheum 1996; 39:2062.
  86. Apan TZ, Gürsel R, Dolgun A. Increased seropositivity of Helicobacter pylori cytotoxin-associated gene-A in Behçet's disease. Clin Rheumatol 2007; 26:885.
  87. Inanc N, Mumcu G, Birtas E, et al. Serum mannose-binding lectin levels are decreased in behcet's disease and associated with disease severity. J Rheumatol 2005; 32:287.
  88. Yavuz S, Elbir Y, Tulunay A, et al. Differential expression of toll-like receptor 6 on granulocytes and monocytes implicates the role of microorganisms in Behcet's disease etiopathogenesis. Rheumatol Int 2008; 28:401.
  89. Seoudi N, Bergmeier LA, Hagi-Pavli E, et al. The role of TLR2 and 4 in Behçet's disease pathogenesis. Innate Immun 2014; 20:412.
  90. Liu X, Wang C, Ye Z, et al. Higher expression of Toll-like receptors 2, 3, 4, and 8 in ocular Behcet's disease. Invest Ophthalmol Vis Sci 2013; 54:6012.
  91. Do JE, Kwon SY, Park S, Lee ES. Effects of vitamin D on expression of Toll-like receptors of monocytes from patients with Behcet's disease. Rheumatology (Oxford) 2008; 47:840.
  92. Liang L, Tan X, Zhou Q, et al. IL-1β triggered by peptidoglycan and lipopolysaccharide through TLR2/4 and ROS-NLRP3 inflammasome-dependent pathways is involved in ocular Behçet's disease. Invest Ophthalmol Vis Sci 2013; 54:402.
  93. Nara K, Kurokawa MS, Chiba S, et al. Involvement of innate immunity in the pathogenesis of intestinal Behçet's disease. Clin Exp Immunol 2008; 152:245.
  94. Lockwood CM, Hale G, Waldman H, Jayne DR. Remission induction in Behçet's disease following lymphocyte depletion by the anti-CD52 antibody CAMPATH 1-H. Rheumatology (Oxford) 2003; 42:1539.
  95. Erkiliç K, Evereklioglu C, Cekmen M, et al. Adenosine deaminase enzyme activity is increased and negatively correlates with catalase, superoxide dismutase and glutathione peroxidase in patients with Behçet's disease: original contributions/clinical and laboratory investigations. Mediators Inflamm 2003; 12:107.
  96. Calis M, Ates F, Yazici C, et al. Adenosine deaminase enzyme levels, their relation with disease activity, and the effect of colchicine on adenosine deaminase levels in patients with Behçet's disease. Rheumatol Int 2005; 25:452.
  97. Canpolat F, Unver M, Eskioğlu F, et al. Serum and erythrocyte adenosine deaminase activities in patients with Behçet's disease. Int J Dermatol 2006; 45:1053.
  98. Hamzaoui K, Hamzaoui A, Guemira F, et al. Cytokine profile in Behçet's disease patients. Relationship with disease activity. Scand J Rheumatol 2002; 31:205.
  99. Raziuddin S, al-Dalaan A, Bahabri S, et al. Divergent cytokine production profile in Behçet's disease. Altered Th1/Th2 cell cytokine pattern. J Rheumatol 1998; 25:329.
  100. Dalghous AM, Freysdottir J, Fortune F. Expression of cytokines, chemokines, and chemokine receptors in oral ulcers of patients with Behcet's disease (BD) and recurrent aphthous stomatitis is Th1-associated, although Th2-association is also observed in patients with BD. Scand J Rheumatol 2006; 35:472.
  101. Sugi-Ikai N, Nakazawa M, Nakamura S, et al. Increased frequencies of interleukin-2- and interferon-gamma-producing T cells in patients with active Behçet's disease. Invest Ophthalmol Vis Sci 1998; 39:996.
  102. Frassanito MA, Dammacco R, Cafforio P, Dammacco F. Th1 polarization of the immune response in Behçet's disease: a putative pathogenetic role of interleukin-12. Arthritis Rheum 1999; 42:1967.
  103. Boiardi L, Salvarani C, Casali B, et al. Intercellular adhesion molecule-1 gene polymorphisms in Behçet's Disease. J Rheumatol 2001; 28:1283.
  104. Ben Ahmed M, Houman H, Miled M, et al. Involvement of chemokines and Th1 cytokines in the pathogenesis of mucocutaneous lesions of Behçet's disease. Arthritis Rheum 2004; 50:2291.
  105. Bardak Y, Aridoğan BC. The demonstration of serum interleukin 6-8, tumor necrosis factor-alpha, complement, and immunoglobulin levels in Behçet's disease with ocular involvement. Ocul Immunol Inflamm 2004; 12:53.
  106. Suzuki N, Nara K, Suzuki T. Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease. Clin Med Res 2006; 4:147.
  107. Imamura Y, Kurokawa MS, Yoshikawa H, et al. Involvement of Th1 cells and heat shock protein 60 in the pathogenesis of intestinal Behcet's disease. Clin Exp Immunol 2005; 139:371.
  108. Turan B, Gallati H, Erdi H, et al. Systemic levels of the T cell regulatory cytokines IL-10 and IL-12 in Bechçet's disease; soluble TNFR-75 as a biological marker of disease activity. J Rheumatol 1997; 24:128.
  109. Katsantonis J, Adler Y, Orfanos CE, Zouboulis CC. Adamantiades-Behçet's disease: serum IL-8 is a more reliable marker for disease activity than C-reactive protein and erythrocyte sedimentation rate. Dermatology 2000; 201:37.
  110. Musabak U, Pay S, Erdem H, et al. Serum interleukin-18 levels in patients with Behçet's disease. Is its expression associated with disease activity or clinical presentations? Rheumatol Int 2006; 26:545.
  111. Turan B, Pfister K, Diener PA, et al. Soluble tumour necrosis factor receptors sTNFR1 and sTNFR2 are produced at sites of inflammation and are markers of arthritis activity in Behçet's disease. Scand J Rheumatol 2008; 37:135.
  112. Durmazlar SP, Ulkar GB, Eskioglu F, et al. Significance of serum interleukin-8 levels in patients with Behcet's disease: high levels may indicate vascular involvement. Int J Dermatol 2009; 48:259.
  113. Mege JL, Dilsen N, Sanguedolce V, et al. Overproduction of monocyte derived tumor necrosis factor alpha, interleukin (IL) 6, IL-8 and increased neutrophil superoxide generation in Behçet's disease. A comparative study with familial Mediterranean fever and healthy subjects. J Rheumatol 1993; 20:1544.
  114. Ozdamar Y, Berker N, Bahar G, et al. Inflammatory mediators and posterior segment involvement in ocular Behcet disease. Eur J Ophthalmol 2009; 19:998.
  115. Akman-Demir G, Tüzün E, Içöz S, et al. Interleukin-6 in neuro-Behçet's disease: association with disease subsets and long-term outcome. Cytokine 2008; 44:373.
  116. Lew W, Chang JY, Jung JY, Bang D. Increased expression of interleukin-23 p19 mRNA in erythema nodosum-like lesions of Behçet's disease. Br J Dermatol 2008; 158:505.
  117. Pay S, Simsek I, Erdem H, et al. Dendritic cell subsets and type I interferon system in Behçet's disease: does functional abnormality in plasmacytoid dendritic cells contribute to Th1 polarization? Clin Exp Rheumatol 2007; 25:S34.
  118. Mantaş C, Direskeneli H, Ekşioglu-Demiralp E, Akoglu T. Serum levels of Th2 cytokines IL-4 and IL-10 in Behçet's disease. J Rheumatol 1999; 26:510.
  119. Vaccarino L, Triolo G, Accardo-Palombo A, et al. Pathological implications of Th1/Th2 cytokine genetic variants in Behçet's disease: Data from a pilot study in a Sicilian population. Biochem Genet 2013; 51:967.
  120. Sugita S, Kawazoe Y, Imai A, et al. Inhibition of Th17 differentiation by anti-TNF-alpha therapy in uveitis patients with Behçet's disease. Arthritis Res Ther 2012; 14:R99.
  121. Shimizu J, Takai K, Fujiwara N, et al. Excessive CD4+ T cells co-expressing interleukin-17 and interferon-γ in patients with Behçet's disease. Clin Exp Immunol 2012; 168:68.
  122. Hamzaoui K. Th17 cells in Behçet's disease: a new immunoregulatory axis. Clin Exp Rheumatol 2011; 29:S71.
  123. Geri G, Terrier B, Rosenzwajg M, et al. Critical role of IL-21 in modulating TH17 and regulatory T cells in Behçet disease. J Allergy Clin Immunol 2011; 128:655.
  124. Liang L, Wang H, Peng XY, Zhao M. [The changes of Th lymphocyte subsets in patients with Behcet disease]. Zhonghua Yan Ke Za Zhi 2011; 47:393.
  125. Lee YJ, Horie Y, Wallace GR, et al. Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease. Ann Rheum Dis 2013; 72:1510.
  126. Nanke Y, Yago T, Kotake S. The Role of Th17 Cells in the Pathogenesis of Behcet's Disease. J Clin Med 2017; 6.
  127. Deniz R, Tulunay-Virlan A, Ture Ozdemir F, et al. Th17-Inducing Conditions Lead to in vitro Activation of Both Th17 and Th1 Responses in Behcet's Disease. Immunol Invest 2017; 46:518.
  128. Kaabachi W, Bouali E, Berraïes A, et al. Interleukin-26 is overexpressed in Behçet's disease and enhances Th17 related -cytokines. Immunol Lett 2017; 190:177.
  129. Freysdottir J, Lau S, Fortune F. Gammadelta T cells in Behçet's disease (BD) and recurrent aphthous stomatitis (RAS). Clin Exp Immunol 1999; 118:451.
  130. Yato H, Matsumoto Y. CD56+ T cells in the peripheral blood of uveitis patients. Br J Ophthalmol 1999; 83:1386.
  131. Eksioglu-Demiralp E, Direskeneli H, Ergun T, et al. Increased CD4+CD16+ and CD4+CD56+ T cell subsets in Behçet's disease. Rheumatol Int 1999; 19:23.
  132. Kim TW, Chung H, Yu HG. Chemokine expression of intraocular lymphocytes in patients with Behçet uveitis. Ophthalmic Res 2011; 45:5.
  133. Bank I, Duvdevani M, Livneh A. Expansion of gammadelta T-cells in Behçet's disease: role of disease activity and microbial flora in oral ulcers. J Lab Clin Med 2003; 141:33.
  134. Clemente A, Cambra A, Munoz-Saá I, et al. Phenotype markers and cytokine intracellular production by CD8+ gammadelta T lymphocytes do not support a regulatory T profile in Behçet's disease patients and healthy controls. Immunol Lett 2010; 129:57.
  135. Freysdottir J, Hussain L, Farmer I, et al. Diversity of gammadelta T cells in patients with Behcet's disease is indicative of polyclonal activation. Oral Dis 2006; 12:271.
  136. Ben Dhifallah I, Chelbi H, Braham A, et al. CTLA-4 +49A/G polymorphism is associated with Behçet's disease in a Tunisian population. Tissue Antigens 2009; 73:213.
  137. Yasuoka H, Okazaki Y, Kawakami Y, et al. Autoreactive CD8+ cytotoxic T lymphocytes to major histocompatibility complex class I chain-related gene A in patients with Behçet's disease. Arthritis Rheum 2004; 50:3658.
  138. Yu HG, Lee DS, Seo JM, et al. The number of CD8+ T cells and NKT cells increases in the aqueous humor of patients with Behçet's uveitis. Clin Exp Immunol 2004; 137:437.
  139. Keino H, Sakai J, Nishioka K, et al. Clonally accumulating T cells in the anterior chamber of Behçet disease. Am J Ophthalmol 2000; 130:243.
  140. Takase H, Sugita S, Taguchi C, et al. Capacity of ocular infiltrating T helper type 1 cells of patients with non-infectious uveitis to produce chemokines. Br J Ophthalmol 2006; 90:765.
  141. Ahn JK, Chung H, Lee DS, et al. CD8brightCD56+ T cells are cytotoxic effectors in patients with active Behcet's uveitis. J Immunol 2005; 175:6133.
  142. Ahn JK, Yu HG, Chung H, Park YG. Intraocular cytokine environment in active Behçet uveitis. Am J Ophthalmol 2006; 142:429.
  143. Guenane H, Hartani D, Chachoua L, et al. [Production of Th1/Th2 cytokines and nitric oxide in Behçet's uveitis and idiopathic uveitis]. J Fr Ophtalmol 2006; 29:146.
  144. Pay S, Erdem H, Pekel A, et al. Synovial proinflammatory cytokines and their correlation with matrix metalloproteinase-3 expression in Behçet's disease. Does interleukin-1beta play a major role in Behçet's synovitis? Rheumatol Int 2006; 26:608.
  145. Todaro M, Zerilli M, Triolo G, et al. NF-kappaB protects Behçet's disease T cells against CD95-induced apoptosis up-regulating antiapoptotic proteins. Arthritis Rheum 2005; 52:2179.
  146. Fujimori K, Oh-i K, Takeuchi M, et al. Circulating neutrophils in Behçet disease is resistant for apoptotic cell death in the remission phase of uveitis. Graefes Arch Clin Exp Ophthalmol 2008; 246:285.
  147. Ozkan Y, Yardim-Akaydin S, Sepici A, et al. Assessment of homocysteine, neopterin and nitric oxide levels in Behçet's disease. Clin Chem Lab Med 2007; 45:73.
  148. Erturan I, Basak PY, Ozturk O, et al. Is there any relationship between serum and urine neopterin and serum interferon-gamma levels in the activity of Behcet's disease? J Eur Acad Dermatol Venereol 2009; 23:1414.
  149. Tulunay A, Dozmorov MG, Ture-Ozdemir F, et al. Activation of the JAK/STAT pathway in Behcet's disease. Genes Immun 2015; 16:170.
  150. Suh CH, Park YB, Song J, et al. Oligoclonal B lymphocyte expansion in the synovium of a patient with Behçet's disease. Arthritis Rheum 2001; 44:1707.
  151. Ekşioglu-Demiralp E, Kibaroglu A, Direskeneli H, et al. Phenotypic characteristics of B cells in Behçet's disease: increased activity in B cell subsets. J Rheumatol 1999; 26:826.
  152. Aydìntug AO, Tokgöz G, D'Cruz DP, et al. Antibodies to endothelial cells in patients with Behçet's disease. Clin Immunol Immunopathol 1993; 67:157.
  153. Direskeneli H, Keser G, D'Cruz D, et al. Anti-endothelial cell antibodies, endothelial proliferation and von Willebrand factor antigen in Behçet's disease. Clin Rheumatol 1995; 14:55.
  154. Matsui T, Kurokawa M, Kobata T, et al. Autoantibodies to T cell costimulatory molecules in systemic autoimmune diseases. J Immunol 1999; 162:4328.
  155. Matsui T, Otsuka M, Maenaka K, et al. Detection of autoantibodies to killer immunoglobulin-like receptors using recombinant fusion proteins for two killer immunoglobulin-like receptors in patients with systemic autoimmune diseases. Arthritis Rheum 2001; 44:384.
  156. Orem A, Cimşit G, Değer O, et al. Autoantibodies against oxidatively modified low-density lipoprotein in patients with Behçet's disease. Dermatology 1999; 198:243.
  157. Feng XG, Ye S, Lu Y, et al. Antikinectin autoantibody in Behçet's disease and several other autoimmune connective tissue diseases. Clin Exp Rheumatol 2007; 25:S80.
  158. Choi CH, Kim TI, Kim BC, et al. Anti-Saccharomyces cerevisiae antibody in intestinal Behçet's disease patients: relation to clinical course. Dis Colon Rectum 2006; 49:1849.
  159. Kurhan-Yavuz S, Direskeneli H, Bozkurt N, et al. Anti-MHC autoimmunity in Behçet's disease: T cell responses to an HLA-B-derived peptide cross-reactive with retinal-S antigen in patients with uveitis. Clin Exp Immunol 2000; 120:162.
  160. Yamamoto JH, Minami M, Inaba G, et al. Cellular autoimmunity to retinal specific antigens in patients with Behçet's disease. Br J Ophthalmol 1993; 77:584.
  161. de Smet MD, Dayan M. Prospective determination of T-cell responses to S-antigen in Behçet's disease patients and controls. Invest Ophthalmol Vis Sci 2000; 41:3480.
  162. Zhao C, Yang P, He H, et al. S-antigen specific T helper type 1 response is present in Behcet's disease. Mol Vis 2008; 14:1456.
  163. Mahesh SP, Li Z, Buggage R, et al. Alpha tropomyosin as a self-antigen in patients with Behçet's disease. Clin Exp Immunol 2005; 140:368.
  164. Okunuki Y, Usui Y, Takeuchi M, et al. Proteomic surveillance of autoimmunity in Behcet's disease with uveitis: selenium binding protein is a novel autoantigen in Behcet's disease. Exp Eye Res 2007; 84:823.
  165. Takeuchi M, Usui Y, Okunuki Y, et al. Immune responses to interphotoreceptor retinoid-binding protein and S-antigen in Behcet's patients with uveitis. Invest Ophthalmol Vis Sci 2010; 51:3067.
  166. Mor F, Weinberger A, Cohen IR. Identification of alpha-tropomyosin as a target self-antigen in Behçet's syndrome. Eur J Immunol 2002; 32:356.
  167. Lu Y, Ye P, Chen SL, et al. Identification of kinectin as a novel Behçet's disease autoantigen. Arthritis Res Ther 2005; 7:R1133.
  168. Kayikçioğlu M, Aksu K, Hasdemir C, et al. Endothelial functions in Behçet's disease. Rheumatol Int 2006; 26:304.
  169. Chambers JC, Haskard DO, Kooner JS. Vascular endothelial function and oxidative stress mechanisms in patients with Behçet's syndrome. J Am Coll Cardiol 2001; 37:517.
  170. Oflaz H, Mercanoglu F, Karaman O, et al. Impaired endothelium-dependent flow-mediated dilation in Behçet's disease: more prominent endothelial dysfunction in patients with vascular involvement. Int J Clin Pract 2005; 59:777.
  171. Triolo G, Accardo-Palumbo A, Triolo G, et al. Enhancement of endothelial cell E-selectin expression by sera from patients with active Behçet's disease: moderate correlation with anti-endothelial cell antibodies and serum myeloperoxidase levels. Clin Immunol 1999; 91:330.
  172. Kansu E, Sahin G, Sahin F, et al. Impaired prostacyclin synthesis by vessel walls in Behçet's disease. Lancet 1986; 2:1154.
  173. Evereklioglu C, Turkoz Y, Er H, et al. Increased nitric oxide production in patients with Behçet's disease: is it a new activity marker? J Am Acad Dermatol 2002; 46:50.
  174. Evereklioglu C, Cekmen M, Ozkiriş A, et al. The pathophysiological significance of red blood cell nitric oxide concentrations in inflammatory Behçet's disease. Mediators Inflamm 2003; 12:255.
  175. Yilmaz G, Sizmaz S, Yilmaz ED, et al. Aqueous humor nitric oxide levels in patients with Behçet disease. Retina 2002; 22:330.
  176. Buldanlioglu S, Turkmen S, Ayabakan HB, et al. Nitric oxide, lipid peroxidation and antioxidant defence system in patients with active or inactive Behçet's disease. Br J Dermatol 2005; 153:526.
  177. Duygulu F, Evereklioglu C, Calis M, et al. Synovial nitric oxide concentrations are increased and correlated with serum levels in patients with active Behçet's disease: a pilot study. Clin Rheumatol 2005; 24:324.
  178. Sahin M, Arslan C, Naziroglu M, et al. Asymmetric dimethylarginine and nitric oxide levels as signs of endothelial dysfunction in Behcet's disease. Ann Clin Lab Sci 2006; 36:449.
  179. Harzallah O, Kerkeni A, Baati T, Mahjoub S. Oxidative stress: correlation with Behçet's disease duration, activity and severity. Eur J Intern Med 2008; 19:541.
  180. Ozdemir R, Barutcu I, Sezgin AT, et al. Vascular endothelial function and plasma homocysteine levels in Behcet's disease. Am J Cardiol 2004; 94:522.
  181. Er H, Evereklioglu C, Cumurcu T, et al. Serum homocysteine level is increased and correlated with endothelin-1 and nitric oxide in Behçet's disease. Br J Ophthalmol 2002; 86:653.
  182. Ateş A, Aydintuğ O, Olmez U, et al. Serum homocysteine level is higher in Behçet's disease with vascular involvement. Rheumatol Int 2005; 25:42.
  183. Sarican T, Ayabakan H, Turkmen S, et al. Homocysteine: an activity marker in Behçet's disease? J Dermatol Sci 2007; 45:121.
  184. La Regina M, Orlandini F, Prisco D, Dentali F. Homocysteine in vascular Behcet disease: a meta-analysis. Arterioscler Thromb Vasc Biol 2010; 30:2067.
  185. Cekmen M, Evereklioglu C, Er H, et al. Vascular endothelial growth factor levels are increased and associated with disease activity in patients with Behçet's syndrome. Int J Dermatol 2003; 42:870.
  186. Bozoglu E, Dinc A, Erdem H, et al. Vascular endothelial growth factor and monocyte chemoattractant protein-1 in Behçet's patients with venous thrombosis. Clin Exp Rheumatol 2005; 23:S42.
  187. Yalçin B, Arda N, Tezel GG, et al. Expressions of vascular endothelial growth factor and CD34 in oral aphthous lesions of Behçet's disease. Anal Quant Cytol Histol 2006; 28:303.
  188. Hamzaoui K, Ayed K, Hamza M, Hamzaoui A. VEGF and mRNA VEGF expression in CSF from Behçet's disease with neurological involvement. J Neuroimmunol 2009; 213:148.
  189. Nam EJ, Han SW, Kim SU, et al. Association of vascular endothelial growth factor gene polymorphisms with behcet disease in a Korean population. Hum Immunol 2005; 66:1068.
  190. Lee KH, Chung HS, Kim HS, et al. Human alpha-enolase from endothelial cells as a target antigen of anti-endothelial cell antibody in Behçet's disease. Arthritis Rheum 2003; 48:2025.
  191. Lee JH, Cho SB, Bang D, et al. Human anti-alpha-enolase antibody in sera from patients with Behçet's disease and rheumatologic disorders. Clin Exp Rheumatol 2009; 27:S63.
  192. Evereklioglu C, Inalöz HS, Kirtak N, et al. Serum leptin concentration is increased in patients with Behçet's syndrome and is correlated with disease activity. Br J Dermatol 2002; 147:331.
  193. Probst K, Fijnheer R, Rothova A. Endothelial cell activation and hypercoagulability in ocular Behçet's disease. Am J Ophthalmol 2004; 137:850.
  194. Espinosa G, Font J, Tàssies D, et al. Vascular involvement in Behçet's disease: relation with thrombophilic factors, coagulation activation, and thrombomodulin. Am J Med 2002; 112:37.
  195. Haznedaroğlu IC, Ozcebe O, Celik I, et al. Haemostatic markers of procoagulant imbalance in Behçet's disease. Eur J Haematol 1996; 57:107.
  196. Navarro S, Ricart JM, Medina P, et al. Activated protein C levels in Behçet's disease and risk of venous thrombosis. Br J Haematol 2004; 126:550.
  197. Akar S, Ozcan MA, Ateş H, et al. Circulated activated platelets and increased platelet reactivity in patients with Behçet's disease. Clin Appl Thromb Hemost 2006; 12:451.
  198. Usküdar O, Erdem A, Demiroğlu H, Dikmenoğlu N. Decreased erythrocyte deformability in Behçet's disease. Clin Hemorheol Microcirc 2005; 33:89.
  199. Tatlican S, Duran FS, Eren C, et al. Reduced erythrocyte deformability in active and untreated Behçet's disease patients. Int J Dermatol 2010; 49:167.
  200. Yurdakul S, Hekim N, Soysal T, et al. Fibrinolytic activity and d-dimer levels in Behçet's syndrome. Clin Exp Rheumatol 2005; 23:S53.
  201. Becatti M, Emmi G, Silvestri E, et al. Neutrophil Activation Promotes Fibrinogen Oxidation and Thrombus Formation in Behçet Disease. Circulation 2016; 133:302.
  202. Leiba M, Seligsohn U, Sidi Y, et al. Thrombophilic factors are not the leading cause of thrombosis in Behçet's disease. Ann Rheum Dis 2004; 63:1445.
  203. Caramaschi P, Poli G, Bonora A, et al. A study on thrombophilic factors in Italian Behcet's patients. Joint Bone Spine 2010; 77:330.
  204. Ricart JM, Ramón LA, Vayá A, et al. Fibrinolytic inhibitor levels and polymorphisms in Behçet disease and their association with thrombosis. Br J Haematol 2008; 141:716.
  205. Espinosa G, Font J, Tàssies D, et al. Vascular involvement in Behçet's disease: relation with thrombophilic factors, coagulation activation, and thrombomodulin. Am J Med 2002; 112:37.
  206. Leiba M, Seligsohn U, Sidi Y, et al. Thrombophilic factors are not the leading cause of thrombosis in Behçet's disease. Ann Rheum Dis 2004; 63:1445.
  207. Chambers JC, Haskard DO, Kooner JS. Vascular endothelial function and oxidative stress mechanisms in patients with Behçet's syndrome. J Am Coll Cardiol 2001; 37:517.
  208. Alan S, Ulgen MS, Akdeniz S, et al. Intima-media thickness and arterial distensibility in Behçet's disease. Angiology 2004; 55:413.
  209. Itoh R, Takenaka T, Okitsu-Negishi S, et al. Interleukin 8 in Behçet's disease. J Dermatol 1994; 21:397.
  210. al-Dalaan A, al-Sedairy S, al-Balaa S, et al. Enhanced interleukin 8 secretion in circulation of patients with Behçet's disease. J Rheumatol 1995; 22:904.
  211. Ureten K, Ertenli I, Oztürk MA, et al. Neutrophil CD64 expression in Behçet's disease. J Rheumatol 2005; 32:849.
  212. Sahin S, Akoğlu T, Direskeneli H, et al. Neutrophil adhesion to endothelial cells and factors affecting adhesion in patients with Behçet's disease. Ann Rheum Dis 1996; 55:128.
  213. Saglam K, Yilmaz MI, Saglam A, et al. Levels of circulating intercellular adhesion molecule-1 in patients with Behçet's disease. Rheumatol Int 2002; 21:146.
  214. Ateş A, Tiryaki OA, Olmez U, Tutkak H. Serum-soluble selectin levels in patients with Behçet's disease. Clin Rheumatol 2007; 26:411.
  215. Turkoz Y, Evereklioglu C, Ozkiriş A, et al. Serum levels of soluble P-selectin are increased and associated with disease activity in patients with Behçet's syndrome. Mediators Inflamm 2005; 2005:237.
  216. Lee MT, Hooper LC, Kump L, et al. Interferon-beta and adhesion molecules (E-selectin and s-intracellular adhesion molecule-1) are detected in sera from patients with retinal vasculitis and are induced in retinal vascular endothelial cells by Toll-like receptor 3 signalling. Clin Exp Immunol 2007; 147:71.
  217. Yamashita S, Suzuki A, Kamada M, et al. Possible physiological roles of proteolytic products of actin in neutrophils of patients with Behçet's disease. Biol Pharm Bull 2001; 24:733.
  218. Yamashita S, Suzuki A, Yanagita T, et al. Characterization of a protease responsible for truncated actin increase in neutrophils of patients with Behçet's disease. Biol Pharm Bull 2001; 24:119.
  219. Orem A, Efe H, Değer O, et al. Relationship between lipid peroxidation and disease activity in patients with Behçet's disease. J Dermatol Sci 1997; 16:11.
  220. Yoshida T, Tanaka M, Sotomatsu A, et al. Serum of Behçet's disease enhances superoxide production of normal neutrophils. Free Radic Res 1998; 28:39.
  221. Kawakami T, Ohashi S, Kawa Y, et al. Elevated serum granulocyte colony-stimulating factor levels in patients with active phase of sweet syndrome and patients with active behcet disease: implication in neutrophil apoptosis dysfunction. Arch Dermatol 2004; 140:570.
  222. Değer O, Orem A, Akyol N, et al. Polymorphonuclear leukocyte elastase levels in patients with Behçet's disease. Clin Chim Acta 1995; 236:129.
  223. Yazici C, Köse K, Caliş M, et al. Increased advanced oxidation protein products in Behçet's disease: a new activity marker? Br J Dermatol 2004; 151:105.
  224. Hamzaoui K, Maître B, Hamzaoui A. Elevated levels of MMP-9 and TIMP-1 in the cerebrospinal fluid of neuro-Behçet's disease. Clin Exp Rheumatol 2009; 27:S52.
  225. Cañete JD, Celis R, Noordenbos T, et al. Distinct synovial immunopathology in Behçet disease and psoriatic arthritis. Arthritis Res Ther 2009; 11:R17.
  226. Sahin S, Lawrence R, Direskeneli H, et al. Monocyte activity in Behçet's disease. Br J Rheumatol 1996; 35:424.
  227. Neves FS, Carrasco S, Goldenstein-Schainberg C, et al. Neutrophil hyperchemotaxis in Behçet's disease: a possible role for monocytes orchestrating bacterial-induced innate immune responses. Clin Rheumatol 2009; 28:1403.
  228. Alipour S, Nouri M, Sakhinia E, et al. Epigenetic alterations in chronic disease focusing on Behçet's disease: Review. Biomed Pharmacother 2017; 91:526.
  229. Hughes T, Ture-Ozdemir F, Alibaz-Oner F, et al. Epigenome-wide scan identifies a treatment-responsive pattern of altered DNA methylation among cytoskeletal remodeling genes in monocytes and CD4+ T cells from patients with Behçet's disease. Arthritis Rheumatol 2014; 66:1648.
  230. Ehrlich GE. Vasculitis in Behçet's disease. Int Rev Immunol 1997; 14:81.
  231. Onder M, Gürer MA. Behçet's disease: an enigmatic vasculitis. Clin Dermatol 1999; 17:571.
  232. Kose AA. Direct immunofluorescence in Behçet's disease: a controlled study with 108 cases. Yonsei Med J 2009; 50:505.
  233. Inaloz HS, Evereklioglu C, Unal B, et al. The significance of immunohistochemistry in the skin pathergy reaction of patients with Behçet's syndrome. J Eur Acad Dermatol Venereol 2004; 18:56.
  234. Ozluk E, Balta I, Akoguz O, et al. Histopathologic Study of Pathergy Test in Behçet's Disease. Indian J Dermatol 2014; 59:630.
  235. Alpsoy E, Uzun S, Akman A, et al. Histological and immunofluorescence findings of non-follicular papulopustular lesions in patients with Behçet's disease. J Eur Acad Dermatol Venereol 2003; 17:521.
  236. Ilknur T, Pabuççuoglu U, Akin C, et al. Histopathologic and direct immunofluorescence findings of the papulopustular lesions in Behçet's disease. Eur J Dermatol 2006; 16:146.
  237. Hatemi G, Bahar H, Uysal S, et al. The pustular skin lesions in Behcet's syndrome are not sterile. Ann Rheum Dis 2004; 63:1450.
  238. Hirohata S. Histopathology of central nervous system lesions in Behçet's disease. J Neurol Sci 2008; 267:41.
  239. Ardalan MR, Sadreddini S, Noshad H, et al. Renal involvement in Behcet's disease. Saudi J Kidney Dis Transpl 2009; 20:618.