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Medline ® Abstract for Reference 44

of 'Pathogenesis of alcoholic liver disease'

44
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Ethanol oxidation by hepatic microsomes: adaptive increase after ethanol feeding.
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Lieber CS, DeCarli LM
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Science. 1968;162(3856):917.
 
Hepatic microsomes contain an ethanol-oxidizing system distinct from alcohol dehydrogenase. In vitro, it has characteristics comparable to those of microsomal drug-detoxifying enzymes and, in vivo, it is capable of adaptation to the administration of ethanol. The existence of this microsomal ethanol-oxidizing system may explain ultrastructural, pharmacological, and biochemical effects of ethanol.
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PMID