Medline ® Abstract for Reference 40
of 'Pathogenesis of alcoholic liver disease'
Variant in PNPLA3 is associated with alcoholic liver disease.
Tian C, Stokowski RP, Kershenobich D, Ballinger DG, Hinds DA
Nat Genet. 2010;42(1):21. Epub 2009 Nov 29.
Two genome-wide association studies (GWAS) have described associations of variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels. We investigated the contributions of these variants to liver disease in Mestizo subjects with a history of alcohol dependence. We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis (unadjusted OR= 2.25, P=1.7 x 10(-10); ancestry-adjusted OR=1.79, P=1.9 x 10(-5)).
Perlegen Sciences, Mountain View, California, USA.