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Medline ® Abstract for Reference 15

of 'Pathogenesis of alcoholic liver disease'

Characterization of a novel arachidonic acid-derived neutrophil chemoattractant.
Roll FJ, Perez HD, Serhan CN
Biochem Biophys Res Commun. 1992;186(1):269.
The oxidation of arachidonic acid in a superoxide-generating environment results in the formation of a potent chemoattractant that appears to be identical to a chemotactic material generated by hepatocytes when they metabolize alcohol. The product was extracted, chromatographed and characterized by physical methods including GC/MS. The physical properties are consistant with the parent structure: 19-hydroperoxy, 20-hydroxyarachidic acid. This novel saturated 20 carbon product, derived from arachidonic acid by free radical-generating reactions, may play a role in the neutrophilic infiltration observed during the course of acute alcoholic hepatitis.
Department of Medicine, University of California, San Francisco 94143.