Pathogenesis of AA amyloidosis
- Peter D Gorevic, MD
Peter D Gorevic, MD
- Professor of Medicine, Rheumatology
- Mount Sinai School of Medicine
- Section Editor
- Helen J Lachmann, MA, MB, BChir, MD, FRCP, FRCPath
Helen J Lachmann, MA, MB, BChir, MD, FRCP, FRCPath
- Section Editor — Amyloidosis
- Reader in Medicine
- University College London
AA amyloid results from the deposition in tissue of serum amyloid A (SAA) protein, which is a major acute phase reactant. Amyloidosis encompasses a group of diseases caused by misfolding and extracellular accumulation of proteins as fibrillar deposits. These fibrils stain with Congo red and produce pathognomonic green birefringence when viewed by microscopy under crossed polarized light. The process of amyloid formation and deposition causes tissue toxicity and progressive organ dysfunction.
The pathogenesis of AA amyloidosis is presented here. The clinical manifestations, diagnosis, and treatment of this disorder, an overview of amyloidosis, and the pathogenesis of other forms of amyloidosis are discussed separately. (See "Causes and diagnosis of secondary (AA) amyloidosis and relation to rheumatic diseases" and "Treatment of secondary (AA) amyloidosis" and "Overview of amyloidosis".)
AMYLOID PRECURSORS AND AMYLOIDOGENESIS
All forms of amyloidosis, including AA amyloidosis, are characterized by codeposition of other molecules, including [1,2]:
●Serum amyloid P component (SAP), a member of the pentraxin family that includes C-reactive protein
●Glycosaminoglycans, notably heparan sulfateTo continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
Subscribers log in hereLiterature review current through: Sep 2017. | This topic last updated: May 04, 2017.References
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