Oxcarbazepine induced toxic epidermal necrolysis - a rare case report

Indian J Pharmacol. 2015 Jul-Aug;47(4):459-61. doi: 10.4103/0253-7613.161279.

Abstract

Carbamazepine, is well known to cause Stevens-Johnson syndrome and toxic epidermal necrolysis(TEN). Oxcarbazepine, a 10-keto analog of carbamazepine, is an anticholinergic, anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy. Its efficacy is similar to carbamazepine but allergic reactions and enzyme induction is low. We describe a case of oxcarbazepine induced TEN, who presented with erythematous ulcerative maculopapular rash.

Keywords: Carbamazepine; Stevens–Johnson syndrome; oxcarbazepine; toxic epidermal necrolysis.

Publication types

  • Case Reports

MeSH terms

  • Anticonvulsants / adverse effects*
  • Carbamazepine / adverse effects
  • Carbamazepine / analogs & derivatives*
  • Erythema / chemically induced
  • Humans
  • Male
  • Middle Aged
  • Oxcarbazepine
  • Stevens-Johnson Syndrome / etiology*
  • Stevens-Johnson Syndrome / pathology

Substances

  • Anticonvulsants
  • Carbamazepine
  • Oxcarbazepine