Oxcarbazepine-induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)

Clin Toxicol (Phila). 2008 Dec;46(10):1093-4. doi: 10.1080/15563650802342104.

Abstract

This is an image and brief case report of a 13-year-old boy who presented with severe rash and systemic symptoms after starting oxcarbazepine. The patient was diagnosed and treated for Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), a syndrome of fever, rash, and internal organ involvement secondary to medication administration. The image illustrates the rash seen with this drug reaction. The report is followed by a brief review of anticonvulsant hypersensitivity syndrome and DRESS.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anticonvulsants / administration & dosage
  • Anticonvulsants / adverse effects*
  • Anticonvulsants / therapeutic use
  • Carbamazepine / administration & dosage
  • Carbamazepine / adverse effects
  • Carbamazepine / analogs & derivatives*
  • Carbamazepine / therapeutic use
  • Drug Eruptions / blood
  • Drug Eruptions / diagnosis
  • Drug Eruptions / drug therapy
  • Drug Eruptions / etiology*
  • Eosinophilia / blood
  • Eosinophilia / chemically induced*
  • Eosinophilia / drug therapy
  • Fever / chemically induced
  • Fever / diagnosis
  • Fever / drug therapy
  • Glucocorticoids / therapeutic use
  • Humans
  • Male
  • Oxcarbazepine
  • Seizures / drug therapy
  • Treatment Outcome

Substances

  • Anticonvulsants
  • Glucocorticoids
  • Carbamazepine
  • Oxcarbazepine