Abstract
Mantle cell lymphoma constitutes one of the lymphomas with poorest prognosis at relapse with limited effective salvage regimens due to advanced age. We present results of a new salvage regimen, rituximab, gemcitabine and oxaliplatin (GEMOX-R), in 14 patients with relapsing (n = 9) or refractory (n = 5) mantle cell lymphoma. The median number of cycles was 5.5 for a total of 72 cycles evaluated in the current study. The median age was 69.5 years with high-risk features. Patients received a mean number of prior treatment lines of 1.79. Sixty-four percent achieved CR (total response rate of 85%). With a median follow-up of 11 months, OS and PFS were 58% and 45% at 12 months. The major toxicity was thrombopenia grade III-IV (35%). Factors related with overall survival were ECOG performance status and a-IPI at GEMOX-R. We conclude that GEMOX-R displays an outstanding efficacy with an excellent toxicity profile in a pretreated elderly population.
Publication types
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Clinical Trial
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Multicenter Study
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Antibodies, Monoclonal / administration & dosage*
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Antibodies, Monoclonal / adverse effects
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Antibodies, Monoclonal, Murine-Derived
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Deoxycytidine / administration & dosage
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Deoxycytidine / adverse effects
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Deoxycytidine / analogs & derivatives*
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Female
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Gemcitabine
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Hematopoietic Stem Cell Transplantation
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Humans
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Lymphoma, Mantle-Cell / drug therapy*
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Lymphoma, Mantle-Cell / mortality
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Lymphoma, Mantle-Cell / pathology*
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Male
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Middle Aged
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Organoplatinum Compounds / administration & dosage*
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Organoplatinum Compounds / adverse effects
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Oxaliplatin
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Recurrence
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Rituximab
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Salvage Therapy
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Survival Analysis
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Transplantation, Autologous
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Treatment Failure
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Treatment Outcome
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Murine-Derived
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Organoplatinum Compounds
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Oxaliplatin
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Deoxycytidine
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Rituximab
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Gemcitabine