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Overview of TORCH infections

Karen E Johnson, MD
Section Editors
Leonard E Weisman, MD
Morven S Edwards, MD
Deputy Editor
Carrie Armsby, MD, MPH


Infections acquired in utero or during the birth process are a significant cause of fetal and neonatal mortality and an important contributor to early and later childhood morbidity. The infected newborn infant may show abnormal growth, developmental anomalies, or multiple clinical and laboratory abnormalities [1]. The original concept of the TORCH perinatal infections was to group five infections with similar presentations, including rash and ocular findings [2]. These five infections are:


Other (syphilis)


Cytomegalovirus (CMV)

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Literature review current through: Nov 2017. | This topic last updated: Sep 19, 2017.
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  1. Neu N, Duchon J, Zachariah P. TORCH infections. Clin Perinatol 2015; 42:77.
  2. Epps RE, Pittelkow MR, Su WP. TORCH syndrome. Semin Dermatol 1995; 14:179.
  3. Maldonado YA, Nizet V, Klein JO, et al. Current concepts of infections of the fetus and newborn infant. In: Infectious Diseases of the Fetus and Newborn Infant, 7th ed, Remington JS, Klein JO, Wilson CB, et al (Eds), Elsevier Saunders, Philadelphia 2011. p.2.
  4. Stamos JK, Rowley AH. Timely diagnosis of congenital infections. Pediatr Clin North Am 1994; 41:1017.
  5. Kinney JS, Kumar ML. Should we expand the TORCH complex? A description of clinical and diagnostic aspects of selected old and new agents. Clin Perinatol 1988; 15:727.
  6. Khan NA, Kazzi SN. Yield and costs of screening growth-retarded infants for torch infections. Am J Perinatol 2000; 17:131.
  7. Cullen A, Brown S, Cafferkey M, et al. Current use of the TORCH screen in the diagnosis of congenital infection. J Infect 1998; 36:185.
  8. Garland SM, Gilbert GL. Investigation of congenital infection--the TORCH screen is not a legitimate test. Paediatric Infectious Diseases Group of the Australasian Society for Infectious Diseases. Med J Aust 1993; 159:346.
  9. de Jong EP, Vossen AC, Walther FJ, Lopriore E. How to use... neonatal TORCH testing. Arch Dis Child Educ Pract Ed 2013; 98:93.
  10. National Newborn Screening and Genetics Resource Center. National newborn screening status report. http://genes-r-us.uthscsa.edu/nbsdisorders.pdf (Accessed on July 20, 2011).
  11. Leland D, French ML, Kleiman MB, Schreiner RL. The use of TORCH titers. Pediatrics 1983; 72:41.
  12. van der Weiden S, de Jong EP, Te Pas AB, et al. Is routine TORCH screening and urine CMV culture warranted in small for gestational age neonates? Early Hum Dev 2011; 87:103.
  13. Reef SE, Plotkin S, Cordero JF, et al. Preparing for elimination of congenital Rubella syndrome (CRS): summary of a workshop on CRS elimination in the United States. Clin Infect Dis 2000; 31:85.
  14. Cherry JD, Adachi K. Rubella virus. In: Feigin and Cherry’s Textbook of Pediatric Infectious Diseases, 7th ed, Cherry JD, Harrison GJ, Kaplan SL, et al (Eds), Elsevier Saunders, Philadelphia 2014. p.2195.
  15. Nickerson JP, Richner B, Santy K, et al. Neuroimaging of pediatric intracranial infection--part 2: TORCH, viral, fungal, and parasitic infections. J Neuroimaging 2012; 22:e52.