Medline ® Abstract for Reference 84
of 'Overview of surgery in the treatment of exocrine pancreatic cancer and prognosis'
Does long-term survival in patients with pancreatic cancer really exist? Results from the CONKO-001 study.
Sinn M, Striefler JK, Sinn BV, Sallmon D, Bischoff S, Stieler JM, Pelzer U, Bahra M, Neuhaus P, Dörken B, Denkert C, Riess H, Oettle H
J Surg Oncol. 2013;108(6):398.
BACKGROUND: Long-term survival (LTS) in patients (pts) with pancreatic cancer is still uncommon, little data is available to identify long-term survivors. The CONKO-001 study, which established gemcitabine after resection as adjuvant therapy, may provide data to answer this question.
METHODS: CONKO-001 pts with an overall survival≥5 years were compared to those who survived<5 years. Central re-evaluation of primary histology was performed. Univariate analysis with theχ(2) -test identified qualifying factors. Logistic regression was used to investigate the influence of these covariates on LTS.
RESULTS: Of the evaluable 354 CONKO-001 pts, 54 (15%) with an overall survival≥5 years were identified. It was possible to obtain tumor specimens of 39 pts (72%). Histological re-evaluation confirmed adenocarcinoma in 38 pts, 1 showed a high-grade neuroendocrine tumor. Univariate analysis for all 53 LTS pts with adenocarcinoma compared to the remaining 300 non-LTS pts revealed as relevant active treatment, tumor grading, tumor size, lymph nodes. No significance could be demonstrated for resection margin, sex, age, Karnofsky performance status, CA 19-9 at study entry. In multivariate analysis, tumor grading, active treatment, tumor size, lymph node involvement were independent prognostic factors for LTS.
CONCLUSION: Long-term survival can be achieved in adenocarcinoma of the pancreas.
Department of Medical Oncology and Haematology, Charité-Universitätsmedizin Berlin, Germany.