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Medline ® Abstract for Reference 74

of 'Overview of paraneoplastic syndromes of the nervous system'

74
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An uncontrolled trial of rituximab for antibody associated paraneoplastic neurological syndromes.
AU
Shams'ili S, de Beukelaar J, Gratama JW, Hooijkaas H, van den Bent M, van 't Veer M, Sillevis Smitt P
SO
J Neurol. 2006;253(1):16.
 
Anti-CD20 monoclonal antibody (rituximab) is effectively used in the treatment of B-cell lymphomas. Recent reports in the literature suggest that antibody associated autoimmune disorders may respond to rituximab. We therefore treated nine patients with anti-Hu or anti-Yo associated paraneoplastic neurological syndromes (PNS) with a maximum of four monthly IV infusions of rituximab (375mg/m(2)). In this uncontrolled, unblinded trial of rituximab, three patients improved>or =1 point on the Rankin Scale (RS). One patient with limbic encephalitis improved dramatically (RS from 5 to 1). Further studies of rituximab in autoantibody associated PNS are warranted.
AD
Dept. of Neurology, Erasmus MC, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
PMID