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Overview of nontuberculous mycobacterial infections in HIV-negative patients

David E Griffith, MD
Section Editor
C Fordham von Reyn, MD
Deputy Editor
Allyson Bloom, MD


Nontuberculous mycobacteria (NTM) species are mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex (eg, M. tuberculosis, Mycobacterium bovis, Mycobacterium africanum, and Mycobacterium microti) and Mycobacterium leprae. NTM are generally free-living organisms that are ubiquitous in the environment. There have been more than 140 NTM species identified.

In broad terms, NTM can cause four clinical syndromes in humans [1,2]:

Pulmonary disease, especially in older persons with or without underlying lung disease and patients with cystic fibrosis, caused primarily by Mycobacterium avium complex (MAC) and Mycobacterium kansasii.

Other species that cause lung disease include Mycobacterium abscessus, Mycobacterium fortuitum, Mycobacterium xenopi, Mycobacterium malmoense, Mycobacterium szulgai, and Mycobacterium simiae (table 1) [3]. Geography plays a prominent role in the epidemiology of NTM pulmonary disease. M. xenopi is relatively more common in Europe, Great Britain, and Canada, while M. malmoense is relatively more common in Scandinavia and Northern Europe [1,4]. (See "Epidemiology of nontuberculous mycobacterial infections".)

Superficial lymphadenitis, especially cervical lymphadenitis, in children caused mostly by MAC, Mycobacterium scrofulaceum, and, in northern Europe, M. malmoense and Mycobacterium haemophilum. (See "Disseminated nontuberculous mycobacterial (NTM) infections and NTM bacteremia in children" and "Nontuberculous mycobacterial lymphadenitis in children".)

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Literature review current through: Nov 2017. | This topic last updated: Oct 08, 2017.
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