Overview of intravenous immune globulin (IVIG) therapy
- Arthur J Silvergleid, MD
Arthur J Silvergleid, MD
- Section Editor — Transfusion Medicine
- Affiliate Associate Professor, Department of Pathology and Cell Biology
- University of South Florida, College of Medicine
- Medical Director, OneBlood, Inc.
- Mark Ballow, MD
Mark Ballow, MD
- Professor of Pediatrics
- All Children’s Hospital
- University of South Florida School of Medicine
- Section Editors
- Stanley L Schrier, MD
Stanley L Schrier, MD
- Editor-in-Chief — Hematology
- Section Editor — Myeloproliferative Disorders; Red Blood Cell Disorders
- Professor of Medicine
- Stanford University School of Medicine
- E Richard Stiehm, MD
E Richard Stiehm, MD
- Editor-in-Chief — Allergy and Immunology
- Section Editor — Immunology and Immunodeficiency
- Distinguished Research Professor of Pediatrics
- David Geffen School of Medicine at UCLA
Immune globulin derived from the plasma of paid and volunteer donors is used in the treatment of an array of disorders, including primary and secondary immune deficiency states and a variety of autoimmune and inflammatory disorders.
This topic will review the indications, proposed mechanisms of action, and administration of intravenous immune globulin (IVIG).
Additional topic reviews discuss the adverse effects of IVIG therapy and the administration of immune globulin by subcutaneous and intramuscular routes. (See "Intravenous immune globulin: Adverse effects" and "Subcutaneous and intramuscular immune globulin therapy".)
The use of IVIG in the treatment of specific disease states is discussed separately. (See 'Indications' below.)
Several terms are used for immune globulin preparations according to the route of administration:
Subscribers log in hereLiterature review current through: Sep 2017. | This topic last updated: Feb 23, 2016.References
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- MECHANISMS OF ACTION
- Protection against infection
- Suppression of inflammatory/autoimmune processes
- Uses for IVIG
- Uses for hyperimmune globulin
- PRETREATMENT TESTING
- PRODUCTION AND COMPOSITION
- SELECTING A PRODUCT
- Selection of IVIG versus other routes
- Selection among IVIG products
- DOSING AND ADMINISTRATION
- Product handling and storage
- Home versus healthcare facility administration
- Dosing in different disorders
- - Immune deficiencies
- - Inflammatory/autoimmune disorders
- Interval between doses
- Infusion rates
- Dosing in obese patients
- VACCINATION OF PATIENTS RECEIVING IVIG
- CONSENT AND RECORD KEEPING
- ADVERSE EFFECTS
- SOCIETY GUIDELINE LINKS
- SUMMARY AND RECOMMENDATIONS