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Overview of endometrial carcinoma

Steven C Plaxe, MD
Arno J Mundt, MD
Section Editors
Barbara Goff, MD
Don S Dizon, MD, FACP
Deputy Editors
Sadhna R Vora, MD
Sandy J Falk, MD, FACOG


Cancer of the endometrium (lining of the uterus) is the most common gynecologic malignancy in developed countries and the second most common in developing countries (cervical cancer is more common). Endometrioid carcinoma is the common site and histologic subtype of endometrial carcinoma and of uterine cancer overall. Endometrioid tumors tend to have a favorable prognosis and typically present at an early stage with abnormal uterine bleeding. Other histologic types of endometrial carcinoma (eg, serous, clear cell) as well as other types of uterine cancer are associated with a poor prognosis.

An overview of endometrial carcinoma will be presented here. Related topics are discussed in detail separately, including:

Histopathology and pathogenesis (see "Endometrial carcinoma: Histopathology and pathogenesis")

Epidemiology and risk factors (see "Endometrial carcinoma: Epidemiology and risk factors")

Clinical features, diagnosis, and screening for high-risk women (see "Endometrial carcinoma: Clinical features and diagnosis")

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Literature review current through: Nov 2017. | This topic last updated: Aug 22, 2017.
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  1. Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin 2015; 65:87.
  2. Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin 2017; 67:7.
  3. http://seer.cancer.gov/statfacts/html/corp.html (Accessed on June 06, 2016).
  4. Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol 1983; 15:10.
  5. Felix AS, Weissfeld JL, Stone RA, et al. Factors associated with Type I and Type II endometrial cancer. Cancer Causes Control 2010; 21:1851.
  6. American Joint Committee on Cancer. Corpus Uteri. In: AJCC Staging Manual, 7th, Springer, New York 2010. p.403.
  7. Benedet JL, Bender H, Jones H 3rd, et al. FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO Committee on Gynecologic Oncology. Int J Gynaecol Obstet 2000; 70:209.
  8. Pecorelli S. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet 2009; 105:103.
  9. Zaino RJ, Kauderer J, Trimble CL, et al. Reproducibility of the diagnosis of atypical endometrial hyperplasia: a Gynecologic Oncology Group study. Cancer 2006; 106:804.
  10. Lewin SN, Herzog TJ, Barrena Medel NI, et al. Comparative performance of the 2009 international Federation of gynecology and obstetrics' staging system for uterine corpus cancer. Obstet Gynecol 2010; 116:1141.
  11. Creasman WT, Odicino F, Maisonneuve P, et al. Carcinoma of the corpus uteri. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer. Int J Gynaecol Obstet 2006; 95 Suppl 1:S105.