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Orthostatic (postural) proteinuria

Michael J Somers, MD
Section Editor
F Bruder Stapleton, MD
Deputy Editor
Melanie S Kim, MD


Orthostatic (also referred to as postural) proteinuria is characterized by an elevated protein excretion while in the upright position and normal protein excretion in a supine or recumbent position. It is the most frequent cause of isolated proteinuria in children, especially adolescents.

The prevalence, pathogenesis, diagnosis, and prognosis of orthostatic proteinuria will be reviewed here. The evaluation of proteinuria in children is discussed separately. (See "Evaluation of proteinuria in children".)


Normal protein excretion — The following are definitions for normal protein excretion in children and adults:

Children – Urinary protein excretion in the normal child is less than 100 mg/m2 per day (<4 mg/m2 per hour) or a total of 150 mg per day. (See "Evaluation of proteinuria in children", section on 'Normal protein excretion'.)

Adults – Urinary protein excretion in the normal adult is less than 50 mg per eight-hour duration or a total of 150 mg per day. (See "Assessment of urinary protein excretion and evaluation of isolated non-nephrotic proteinuria in adults", section on 'Amounts of proteinuria'.)

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Literature review current through: Nov 2017. | This topic last updated: Aug 23, 2016.
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