Nivolumab-associated Lambert-Eaton myasthenic syndrome and cerebellar dysfunction in a patient with a neuroendocrine tumor

Muscle Nerve. 2021 Mar;63(3):E18-E21. doi: 10.1002/mus.27141. Epub 2020 Dec 29.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Amifampridine / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Calcium Channels, P-Type
  • Calcium Channels, Q-Type
  • Cerebellar Diseases / chemically induced*
  • Cerebellar Diseases / drug therapy
  • Cerebellar Diseases / immunology
  • Cerebellar Diseases / physiopathology
  • Cerebellar Neoplasms / secondary
  • Cerebellar Neoplasms / therapy*
  • Female
  • Glucocorticoids / therapeutic use
  • Humans
  • Immune Checkpoint Inhibitors / adverse effects*
  • Immunoglobulins, Intravenous / therapeutic use
  • Immunologic Factors / therapeutic use
  • Lambert-Eaton Myasthenic Syndrome / chemically induced*
  • Lambert-Eaton Myasthenic Syndrome / drug therapy
  • Lambert-Eaton Myasthenic Syndrome / immunology
  • Lambert-Eaton Myasthenic Syndrome / physiopathology
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / pathology
  • Lung Neoplasms / therapy
  • Lymph Nodes / diagnostic imaging
  • Magnetic Resonance Imaging
  • Middle Aged
  • Nerve Degeneration / chemically induced*
  • Nerve Degeneration / drug therapy
  • Nerve Degeneration / immunology
  • Nerve Degeneration / physiopathology
  • Neuroendocrine Tumors / secondary
  • Neuroendocrine Tumors / therapy*
  • Neuromuscular Agents / therapeutic use
  • Nivolumab / adverse effects*
  • Positron Emission Tomography Computed Tomography
  • Prednisone / therapeutic use
  • Radiosurgery
  • Radiotherapy
  • Rituximab / therapeutic use
  • Small Cell Lung Carcinoma / diagnostic imaging
  • Small Cell Lung Carcinoma / secondary
  • Small Cell Lung Carcinoma / therapy
  • Tomography, X-Ray Computed

Substances

  • Calcium Channels, P-Type
  • Calcium Channels, Q-Type
  • Glucocorticoids
  • Immune Checkpoint Inhibitors
  • Immunoglobulins, Intravenous
  • Immunologic Factors
  • Neuromuscular Agents
  • Nivolumab
  • Rituximab
  • Amifampridine
  • Prednisone

Supplementary concepts

  • Cerebellar degeneration, subacute