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Neuromuscular manifestations of systemic sclerosis (scleroderma)

Monica L Piecyk, MD
Peter H Schur, MD
Section Editor
John S Axford, DSc, MD, FRCP, FRCPCH
Deputy Editor
Monica Ramirez Curtis, MD, MPH


The literature addressing neurologic involvement in systemic sclerosis (SSc; scleroderma) principally consists of case series and case reports. It includes the following categories, listed in approximate order of frequency:

Cranial, entrapment, peripheral, cutaneous, autonomic neuropathies


Central nervous system involvement, including headache, seizures, stroke, vascular disease, radiculopathy, and myelopathy

In general, however, central nervous system (CNS) involvement due to SSc is rare, but complications of other organ damage may have neurologic manifestations. Examples include renal failure, uncontrolled hypertension, and heart or respiratory failure.

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Literature review current through: Nov 2017. | This topic last updated: Aug 26, 2016.
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