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Medline ® Abstract for Reference 5

of 'Neonatal acute kidney injury: Evaluation, management, and prognosis'

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Nonoliguric acute renal failure in the newborn: a prospective evaluation of diagnostic indexes.
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Grylack L, Medani C, Hultzen C, Sivasubramanian K, Davitt MK, Jose P, Scanlon JW
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Am J Dis Child. 1982;136(6):518.
 
Fifteen newborn babies with azotemia without oliguria were studied. Group A infants had increased BUN levels and decreased creatinine clearance (Ccr) for gestational and postnatal age, and were compared with group B infants, who had increased BUN levels and normal Ccr. The Ccr was 0.35 mL/min in group A and 0.76 mL/min in group B. Urine volume during the same period was 2.45 mL/kg/hr in group A and 4.66 mL/kg/hr in group B. No significant differences in fractional sodium excretion; urine to plasma ratios of creatinine, osmolality, and sodium; and renal failure index were present between the two groups. The results suggest that nonoliguric acute renal failure is a diagnostic entity in the newborn. The Ccr is the most useful indicator for defining renal function in the presence of azotemia and normal urine volume.
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