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Neoadjuvant chemotherapy for newly diagnosed advanced ovarian cancer

Panagiotis A Konstantinopoulos, MD, PhD
Robert E Bristow, MD, MBA
Section Editors
Barbara Goff, MD
Don S Dizon, MD, FACP
Deputy Editor
Sadhna R Vora, MD


Epithelial cancers of ovarian, fallopian tube, and peritoneal origin exhibit similar clinical characteristics and behavior. As such, these are often combined together and define epithelial ovarian cancer (EOC) in clinical trials and clinical practice. This topic will consider all three histologies under the heading EOC.

EOC is the most common cause of death among women with gynecologic malignancies and the fifth leading cause of cancer death in women in the United States. Approximately 75 percent of women have stage III (disease that has spread throughout the peritoneal cavity or that involves lymph nodes) or stage IV (disease spread to more distant sites) disease at diagnosis. (See "Epithelial carcinoma of the ovary, fallopian tube, and peritoneum: Clinical features and diagnosis".)

For most patients, EOC is treated surgically and followed by adjuvant platinum and taxane-based chemotherapy. However, neoadjuvant chemotherapy (NACT) prior to definitive surgery is an alternative option in selected patients. This topic will review the rationale and administration of NACT for EOC. Other relevant topics in the treatment of EOC include:

(See "Cancer of the ovary, fallopian tube, and peritoneum: Staging and initial surgical management".)

(See "Adjuvant therapy of early stage (stage I and II) epithelial ovarian, fallopian tubal, or peritoneal cancer".)

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Literature review current through: Nov 2017. | This topic last updated: Feb 08, 2017.
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