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Medline ® Abstract for Reference 16

of 'Musculoskeletal manifestations of amyloidosis'

Amyloid arthropathy and Waldenström macroglobulinemia.
Gisserot O, Landais C, Cremades S, Terrier JP, Leyral G, Bernard P, de Jauréguiberry JP
Joint Bone Spine. 2006;73(4):456.
Amyloid arthropathy occurs chiefly as a manifestation of beta(2) microglobulin amyloidosis in patients receiving chronic hemodialysis. AL amyloidosis complicating multiple myeloma is a less common cause. Amyloid arthropathy is exceedingly rare in patients with Waldenström macroglobulinemia. We report a case characterized by lymphoplasmocytoid malignancy with monoclonal IgM production and amyloid arthropathy manifesting as bilateral symmetric polyarthritis. A synovial membrane biopsy established the diagnosis. Chemotherapy was effective in alleviating the joint manifestations. Joint symptoms in patients with monoclonal gammopathies, including those characterized by IgM secretion, should suggest amyloid arthropathy. Treatment of the blood disease may improve the joint symptoms.
Internal Medicine and Oncology Department, Sainte-Anne Armed Forces Teaching Hospital, 83800 Toulon Naval, France. oncologie@sianteanne.org