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Multifocal motor neuropathy

Dale Lange, MD
Jessica Robinson-Papp, MD
Section Editor
Jeremy M Shefner, MD, PhD
Deputy Editor
John F Dashe, MD, PhD


Multifocal motor neuropathy (MMN), also known as multifocal motor neuropathy with conduction block, is a rare neuropathy characterized by progressive asymmetric weakness and atrophy without sensory abnormalities, a presentation similar to that of motor neuron disease. This review will discuss the clinical aspects of MMN. Other immune-mediated neuropathies are discussed separately. (See "Immune-mediated neuropathies".)


MMN is considered an immune-mediated disorder given the following observations [1-3]:

Clinical improvement with intravenous immune globulin therapy

The presence of anti-GM1 antibodies in many but not all patients

A perivascular lymphocytic infiltration observed on nerve biopsy in some reports

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Literature review current through: Dec 2017. | This topic last updated: May 31, 2017.
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