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Molecular genetics of chronic myeloid leukemia

Richard A Van Etten, MD, PhD
Section Editor
Richard A Larson, MD
Deputy Editor
Alan G Rosmarin, MD


Chronic myeloid leukemia (CML, also known as chronic myelocytic, myelogenous, or granulocytic leukemia) is classified as one of the myeloproliferative neoplasms, along with polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). (See "Overview of the myeloproliferative neoplasms".)

This group of diseases shares several distinct features:

They are clonal disorders of hematopoiesis that arise in a hematopoietic stem or early progenitor cell.

They are characterized by the dysregulated production of a particular lineage of mature myeloid cells with fairly normal differentiation.

They exhibit a variable tendency to progress to acute leukemia.

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Literature review current through: Nov 2017. | This topic last updated: Sep 29, 2015.
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