Cushing's syndrome

Lancet. 2006 May 13;367(9522):1605-17. doi: 10.1016/S0140-6736(06)68699-6.

Abstract

Cushing's syndrome results from lengthy and inappropriate exposure to excessive glucocorticoids. Untreated, it has significant morbidity and mortality. The syndrome remains a challenge to diagnose and manage. Here, we review the current understanding of pathogenesis, clinical features, diagnostic, and differential diagnostic approaches. We provide diagnostic algorithms and recommendations for management.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adrenocorticotropic Hormone / metabolism
  • Adrenocorticotropic Hormone / physiology
  • Cushing Syndrome* / diagnosis
  • Cushing Syndrome* / physiopathology
  • Cushing Syndrome* / therapy
  • Diagnosis, Differential
  • Female
  • Humans
  • Hydrocortisone / blood
  • Hydrocortisone / urine
  • Male

Substances

  • Adrenocorticotropic Hormone
  • Hydrocortisone