Second-line anticonvulsant treatment of neonatal seizures: a video-EEG monitoring study

Neurology. 2004 Feb 10;62(3):486-8. doi: 10.1212/01.wnl.0000106944.59990.e6.

Abstract

The authors conducted a randomized trial of second-line anticonvulsant treatments for neonates. The response to treatment was assessed using continuous video-EEG because the clinical diagnosis of seizure in neonates is known to be unreliable. Of 27 neonates with EEG-confirmed seizures, 5 were excluded because of protocol violations, and 11 responded to phenobarbitone in a dose of 40 mg/kg as first line. Three of five neonates treated with lignocaine responded. Six neonates were treated with benzodiazepines as second line: None responded, and their neurodevelopmental outcome was poor.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anticonvulsants / therapeutic use*
  • Clonazepam / therapeutic use
  • Drug Resistance
  • Electroencephalography*
  • Epilepsy / congenital
  • Epilepsy / drug therapy*
  • Female
  • Humans
  • Infant, Newborn
  • Lidocaine / therapeutic use
  • Male
  • Midazolam / therapeutic use
  • Phenobarbital / therapeutic use
  • Psychomotor Disorders / etiology
  • Treatment Failure
  • Video Recording

Substances

  • Anticonvulsants
  • Clonazepam
  • Lidocaine
  • Midazolam
  • Phenobarbital