Continuous infusion meropenem and ticarcillin-clavulanate in pediatric cystic fibrosis patients

Pediatr Pulmonol. 2014 Mar;49(3):302-6. doi: 10.1002/ppul.22820. Epub 2013 Jun 17.

Abstract

Aztreonam, cefepime, and ceftazidime are anti-pseudomonal beta-lactam antibiotics which have been previously reported to be administered by continuous infusion (CI) in pediatric CF patients. We present two cases administering intravenous (IV) meropenem and ticarcillin-clavulanate by CI in pediatric CF patients. The delivery of beta-lactam antibiotics via CI should be considered in order to optimize the pharmacodynamics (PD) of beta-lactams in the treatment of acute pulmonary exacerbations (APE).

Keywords: Inquilinus limosus; Pseudomonas aeruginosa; antibiotics; beta-lactams.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / administration & dosage*
  • Clavulanic Acids / administration & dosage
  • Cystic Fibrosis / complications
  • Cystic Fibrosis / drug therapy*
  • Cystic Fibrosis / microbiology
  • Female
  • Gram-Negative Bacterial Infections / complications
  • Gram-Negative Bacterial Infections / drug therapy
  • Humans
  • Infusions, Intravenous
  • Meropenem
  • Pneumonia, Bacterial / complications
  • Pneumonia, Bacterial / drug therapy*
  • Pseudomonas Infections / complications
  • Pseudomonas Infections / drug therapy*
  • Pseudomonas aeruginosa / isolation & purification
  • Rhodospirillaceae / isolation & purification
  • Thienamycins / administration & dosage*
  • Ticarcillin / administration & dosage

Substances

  • Anti-Bacterial Agents
  • Clavulanic Acids
  • Thienamycins
  • ticarcillin-clavulanic acid
  • Ticarcillin
  • Meropenem