Abstract
The effect of increasing meropenem concentrations up to 250 mg/L, as might occur if 3 g was given as a single daily intravenous dose, was investigated in terms of bactericidal activity, post antibiotic effect (PAE) and modified controlled effective regrowth time (mCERT). Increasing the meropenem concentration above 50 mg/L did not result in increased bacterial killing, while concentrations over 75 mg/L did not result in longer PAE or mCERT.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Enterobacter / drug effects
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Enterobacter / growth & development
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Escherichia coli / drug effects
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Escherichia coli / growth & development
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Gram-Negative Bacteria / drug effects*
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Gram-Negative Bacteria / growth & development*
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Gram-Positive Bacteria / drug effects*
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Gram-Positive Bacteria / growth & development*
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Kinetics
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Klebsiella / drug effects
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Klebsiella / growth & development
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Meropenem
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Microbial Sensitivity Tests
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / growth & development
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / growth & development
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Thienamycins / pharmacology*