Memantine is an N-methyl-D-aspartate glutamate receptor antagonist that may improve cognitive functions in patients with Alzheimer's disease. It is predominantly excreted unchanged via the kidneys, and patients with decreased creatinine clearance must be treated with lower doses of memantine. However, it is unclear whether memantine itself can lead to renal dysfunction and/or hyperkalaemia. We report a patient with renal impairment and hyperkalaemia possibly associated with memantine administration.
Keywords: Alzheimer's disease; hyperkalaemia; memantine; renal impairment.
© 2013 The Authors. Psychogeriatrics © 2013 Japanese Psychogeriatric Society.