Measurement and clinical significance of antinuclear antibodies
- Donald B Bloch, MD
Donald B Bloch, MD
- Associate Professor of Medicine
- Harvard Medical School
The detection of antinuclear antibodies (ANA) in serum facilitates the diagnosis of patients with systemic lupus erythematosus (SLE) and related autoimmune diseases. Conversely, the absence of ANA in the serum of a patient with suspected SLE also provides important information in that it makes the diagnosis much less likely. This topic will review:
●The indirect immunofluorescence test for ANA
●The significance of common ANA staining patterns and titer of ANA
●Additional techniques to detect ANA
●Advantages and disadvantages of methods to detect ANATo continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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- TECHNIQUES TO DETECT ANA
- Indirect immunofluorescence test for ANA
- - Significance of ANA staining patterns
- - Significance of ANA titer
- Solid phase assays
- ADVANTAGES AND DISADVANTAGES OF METHODS TO DETECT ANA
- Indirect immunofluorescence test
- Solid phase assays
- CLINICAL LIMITATIONS OF ANA TESTING
- INDICATIONS FOR ORDERING ADDITIONAL, SPECIFIC TESTS FOR AUTOANTIBODIES
- THE SIGNIFICANCE OF A POSITIVE TEST FOR ANA IN THE AS-YET UNDIAGNOSED PATIENT WITH MUSCULOSKELETAL SYMPTOMS
- SUMMARY AND RECOMMENDATIONS