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Medline ® Abstract for Reference 73

of 'Maternal adaptations to pregnancy: Hematologic changes'

TAFI antigen and D-dimer levels during normal pregnancy and at delivery.
Chabloz P, Reber G, Boehlen F, Hohlfeld P, de Moerloose P
Br J Haematol. 2001;115(1):150.
We have investigated whether the levels of thrombin-activatable fibrinolysis inhibitor (TAFI) were correlated with D-dimer levels during pregnancy and at delivery. From the 10th week of pregnancy to delivery, 519 samples from 144 women (mean age 29.3 +/- 5, range 19-43) were obtained. We confirm the gradual increase of D-dimer levels, and provide reference intervals for D-dimer measurements throughout normal pregnancy. TAFI levels increased moderately during pregnancy but no inverse correlation with D-dimer levels was observed.
Department of Gynaecology and Obstetrics, Lausanne University Hospital, Lausanne, Switzerland.