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Medline ® Abstract for Reference 68

of 'Maternal adaptations to pregnancy: Hematologic changes'

[Markers of hypercoagulability during pregnancy: thrombin-antithrombin-III complexes and D dimer].
Senent M, Bellart J, Zuazu-Jausoro I, Oliver A, Montserrat I, Ribera L, Tirado I, Cabero L, Fontcuberta J
Sangre (Barc). 1991;36(1):21.
Pregnancy can be regarded as a secondary hyper-coagulability state. The development of thrombin-anti-thrombin complexes (TATC), D dimer and anti-thrombin III (AT III) was analysed in the present work on 33 pregnant women. A significant increase of the TATC records was found between the first and third trimesters and between the second and third trimesters (p = 0.005 and p = 0.02, respectively). The AT III values were within the normal range. The values of the D dimer increased progressively during pregnancy, but only the figures achieved in the third trimester were statistically significant with respect to the control group (p = 0.14). The increase of TATC and D dimer during pregnancy are considered as hypercoagulability.
Servicios de Hematología y Ginecología, Hospital de la Santa Creu i Sant Pau, Barcelona.