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Medline ® Abstract for Reference 18

of 'Maternal adaptations to pregnancy: Hematologic changes'

Serum erythropoietin quantitation in pregnancy using an enzyme-linked immunoassay.
Harstad TW, Mason RA, Cox SM
Am J Perinatol. 1992;9(4):233.
During normal pregnancy there is a decrease in the hematocrit due to a disproportionate increase in the blood volume compared with the red cell mass. Using a new enzyme-linked immunoassay (Amgen Diagnostics), serum erythropoietin was quantified in normal nonanemic pregnancies throughout gestation and in third trimester anemic patients. We found that the mean hematocrit in normal pregnancy reached a nadir late in the second trimester and the serum erythropoietin plateaued at a 50% increase. Those pregnancies complicated by anemia defined by a hematocrit less than 30 vol% demonstrated a statistically significant increase in serum erythropoietin above those not anemic.
Department of Obstetrics&Gynecology, University of Texas Southwestern Medical Center, Dallas.