[Markers of hypercoagulability during pregnancy: thrombin-antithrombin-III complexes and D dimer]

Sangre (Barc). 1991 Feb;36(1):21-4.
[Article in Spanish]

Abstract

Pregnancy can be regarded as a secondary hyper-coagulability state. The development of thrombin-anti-thrombin complexes (TATC), D dimer and anti-thrombin III (AT III) was analysed in the present work on 33 pregnant women. A significant increase of the TATC records was found between the first and third trimesters and between the second and third trimesters (p = 0.005 and p = 0.02, respectively). The AT III values were within the normal range. The values of the D dimer increased progressively during pregnancy, but only the figures achieved in the third trimester were statistically significant with respect to the control group (p = 0.14). The increase of TATC and D dimer during pregnancy are considered as hypercoagulability.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antithrombin III / analysis*
  • Blood Coagulation*
  • Female
  • Fibrin Fibrinogen Degradation Products / analysis*
  • Humans
  • Pregnancy / blood*
  • Pregnancy Trimester, Third
  • Prospective Studies
  • Thrombin / analysis*

Substances

  • Fibrin Fibrinogen Degradation Products
  • fibrin fragment D
  • Antithrombin III
  • Thrombin