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Management of pulmonary sequelae and complications of coccidioidomycosis

John N Galgiani, MD
Shari L Meyerson, MD
Section Editor
Carol A Kauffman, MD
Deputy Editor
Jennifer Mitty, MD, MPH


Approximately two-thirds of persons experience few or no symptoms following respiratory exposure to arthroconidia of Coccidioides spp. Those who become ill typically develop symptoms, such as cough, pleurisy, fever, and weight loss, one to three weeks after exposure; these symptoms generally resolve over the ensuing several months [1,2]. Marked fatigue, one of the common manifestations of the primary infection, may be especially prolonged and slow to resolve. Whether or not the primary exposure is recognized, most infections are self-limited without additional events or complications.

Occasional patients have persistent pulmonary consequences of coccidioidomycosis that require medical and/or surgical management, and these will be reviewed here. There are three major persistent pulmonary manifestations:

Residual pulmonary nodules

Coccidioidal cavities

Diffuse reticulonodular pneumonia


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Literature review current through: Jul 2017. | This topic last updated: Jan 24, 2014.
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