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Management of non-Rhesus (D) red blood cell alloantibodies during pregnancy

Melanie S Kennedy, MD
Kenneth J Moise Jr, MD
Section Editors
Arthur J Silvergleid, MD
Louise Wilkins-Haug, MD, PhD
Deputy Editors
Jennifer S Tirnauer, MD
Vanessa A Barss, MD, FACOG


Maternal alloantibodies to red blood cell (RBC) antigens other than Rh(D) are capable of causing clinically significant hemolysis of fetal and newborn RBCs, known as hemolytic disease of the fetus and newborn (HDFN). Once an alloantibody is identified, appropriate testing and estimation of the risk to the fetus are essential to obstetric care.

This topic review discusses the clinical significance of RBC alloantibodies other than anti-Rh(D) during pregnancy. Separate topic reviews discuss Rh(D) alloimmunization, fetal transfusion, and postnatal management of HDFN.

(See "Prevention of Rhesus (D) alloimmunization in pregnancy".)

(See "Overview of Rhesus D alloimmunization in pregnancy".)

(See "Management of pregnancy complicated by Rhesus (D) alloimmunization".)

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Literature review current through: Nov 2017. | This topic last updated: Jul 03, 2017.
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