Management of low-grade serous carcinomas of the ovary
- David M Gershenson, MD
David M Gershenson, MD
- J Taylor Wharton MD Distinguished Chair in Gynecologic Oncology
- Professor of Gynecologic Oncology
- The University of Texas MD Anderson Cancer Center
- Michael J Birrer, MD, PhD
Michael J Birrer, MD, PhD
- Professor of Medicine
- Harvard Medical School
- Section Editors
- Barbara Goff, MD
Barbara Goff, MD
- Section Editor — Gynecologic Oncology
- Professor of Gynecologic Oncology
- University of Washington
- Don S Dizon, MD, FACP
Don S Dizon, MD, FACP
- Section Editor – Gynecologic Oncology
- Head of Women's Cancers, Lifespan Cancer Institute
- Director of Medical Oncology, Rhode Island Hospital
- Associate Professor of Medicine, Warren Alpert Medical School of Brown University
Ovarian cancer is the second most common gynecologic malignancy and the most common cause of gynecologic cancer death in the United States. (See "Epithelial carcinoma of the ovary, fallopian tube, and peritoneum: Epidemiology and risk factors", section on 'Epidemiology'.)
The most common epithelial ovarian cancer histologic subtype is serous. Approximately 90 percent of serous carcinomas are high-grade, and 10 percent are low-grade. Low-grade serous carcinoma of the ovary or peritoneum appears to exist on a continuum with serous borderline tumors, which are likely precursor lesions, and has a distinct pathology, clinical behavior, and prognosis compared with high-grade serous carcinoma. Thus, a diagnosis of low-grade serous carcinoma may be made de novo or following an original diagnosis of serous borderline tumor.
The pathogenesis, clinical presentation, diagnosis, and treatment of low-grade serous carcinoma will be reviewed here. Aspects of the management of ovarian and peritoneal carcinomas (of higher grade) as well as borderline ovarian tumors are discussed elsewhere.To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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- CLINICAL PRESENTATION
- Preoperative management
- - Imaging
- - Tumor markers
- - Genetic testing for hereditary cancer syndromes
- - Adjuvant treatment
- Stage IA, IB, and IC
- Stage II to IV
- Those in whom primary resection is not feasible
- Recurrent or metastatic disease
- Is there a role for angiogenesis inhibitors?
- INVESTIGATIONAL APPROACHES
- SUMMARY AND RECOMMENDATIONS