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Medline ® Abstract for Reference 92

of 'Management of acute exacerbations of asthma in adults'

92
TI
Inhaled furosemide in the treatment of acute exacerbations of asthma
AU
Hinckley JB
SO
Acad Emerg Med. 2000;7(10):1167.
 
Inhalation of the loop diuretic furosemide has been found to protect against challenges with bronchoconstrictive agents. OBJECTIVE: To determine if furosemide has any objective and/or subjective therapeutic effect on adult patients with acute exacerbations of asthma, above and beyond the effects of B2 agonists and oral glucocorticoids. METHODS: 35 adult patients with acute exacerbations of asthma were randomized and recruited into the study if they had a prior history of asthma, and<10 pack-year smoking history, had not received pre-hospital B2 agonists, were not pregnant, and had no sulfonamide allergy. A double blind study design was employed. One group received albuterol 5 mg with placebo and one group received albuterol 5 mg with furosemide 40 mg in their nebulizer. Both groups received prednisone 80 mg po. PEFRs were obtained before initiation of treatment and 30 and 60 minutes thereafter. A 10 point dyspnea scale was also employed at initiation of treatment and 30 and 60 minutes thereafter. Physicians were permitted to give rescue albuterol treatments as deemed necessary. RESULTS: There was no difference in the treatment arms with respect to PEFR, dyspnea score, or number of rescue albuterol treatments at 30 and 60 minutes. CONCLUSIONS: We found no statistical benefit to adding furosemide to a regimen consisting of prednisone and optimal doses of B2 agonist. We conclude that there is not a current role for furosemide in acute exacerbations of asthma.
AD
OUCOM / Doctors Hospital, Columbus, OH.
PMID