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Medline ® Abstract for Reference 62

of 'Management of acute exacerbations of asthma in adults'

62
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Use of ketamine in asthmatic children to treat respiratory failure refractory to conventional therapy.
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Rock MJ, Reyes de la Rocha S, L'Hommedieu CS, Truemper E
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Crit Care Med. 1986;14(5):514.
 
We treated two pediatric patients suffering respiratory failure associated with status asthmaticus. Neither patient responded to maximal bronchodilatory therapy and mechanical ventilation; however, continuous infusion of ketamine (1.0 to 2.5 mg/kg X h) immediately improved airway obstruction. Ketamine appears to increase catecholamine levels and directly relax bronchial smooth muscle. Except for increased secretions during the infusion, our patients showed no immediate or long-term sequelae from ketamine therapy. However, ketamine should only be used for asthmatics whose respiratory failure does not respond to conventional management and mechanical ventilation.
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PMID