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Management and prognosis of the thalassemias

Edward J Benz, Jr, MD
Section Editor
Stanley L Schrier, MD
Deputy Editor
Jennifer S Tirnauer, MD


Management of the thalassemia syndromes can be challenging due to the numerous potential disease complications and the lack of available therapies other than transfusion and hematopoietic cell transplantation, both of which have associated morbidities and costs. This topic review discusses the approach to managing alpha and beta thalassemias, including transfusion-dependent and transfusion-independent (mild or intermediate severity) disease.

Separate topic reviews discuss other issues in the thalassemias:

Scope of the disease – (see "Public health issues in the thalassemic syndromes")

Pathophysiology – (see "Pathophysiology of alpha thalassemia" and "Pathophysiology of beta thalassemia" and "Molecular pathology of the thalassemic syndromes" and "Introduction to hemoglobin mutations")

Prenatal screening – (see "Prenatal screening and testing for hemoglobinopathy")

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Literature review current through: Sep 2017. | This topic last updated: Oct 16, 2017.
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