Malignancy in dermatomyositis and polymyositis
- Marc L Miller, MD
Marc L Miller, MD
- Clinical Assistant Professor of Medicine
- Tufts University School of Medicine
- Section Editors
- Ira N Targoff, MD
Ira N Targoff, MD
- Section Editor — Muscle Disease
- Professor of Medicine, Section of Rheumatology
- University of Oklahoma Health Sciences Center
- Jeremy M Shefner, MD, PhD
Jeremy M Shefner, MD, PhD
- Section Editor — Neuromuscular Disease
- Professor and Chair of Neurology, Barrow Neurological Institute
- Professor of Neurology, University of Arizona, Phoenix
- Clinical Professor of Neurology, Creighton University
Dermatomyositis (DM) and polymyositis (PM) are idiopathic inflammatory myopathies characterized by proximal skeletal muscle weakness and evidence of muscle inflammation. DM, unlike PM, is characterized by the presence of various cutaneous manifestations. DM and PM may also be associated with inflammatory arthritis, interstitial lung disease, Raynaud phenomenon, and the presence of autoantibodies.
An association between inflammatory myopathy and cancer has been recognized since the report of two cases of PM and gastric cancer in 1916 . The association is stronger for patients with DM than PM. The evidence for an association between cancer and inflammatory myopathy includes:
●Epidemiologic evidence from large population studies
●Temporal relationship between the diagnosis of cancer and myopathy
●The improvement or resolution of myopathy after treatment of the cancer
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- Types of malignancies
- Temporal relationship
- RISK FACTORS
- Clinical risk factors
- Serum autoantibodies
- APPROACH TO SCREENING
- Initial screening for malignancy
- Post-treatment surveillance
- IMPACT OF MALIGNANCY ON DISEASE SEVERITY
- SUMMARY AND RECOMMENDATIONS