Abstract
One hundred and ninety-nine children received lorazepam 0.05 mg kg-1 or trimeprazine 3 mg kg-1 as oral premedication in a double-blind trial. Lorazepam proved more palatable and produced a cheerful demeanour, but possessed no significant advantages on overall assessment before surgery. Following operation, restlessness with vomiting, and evidence of retrograde amnesia occurred more frequently with lorazepam.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Administration, Oral
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Anti-Anxiety Agents* / administration & dosage
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Child
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Child Behavior / drug effects
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Child, Preschool
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Female
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Heart Rate / drug effects
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Humans
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Lorazepam* / administration & dosage
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Lorazepam* / pharmacology
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Male
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Preanesthetic Medication*
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Trimeprazine* / administration & dosage
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Trimeprazine* / pharmacology
Substances
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Anti-Anxiety Agents
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Trimeprazine
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Lorazepam