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Localized lichen myxedematosus

Author
Franco Rongioletti, MD
Section Editor
Jeffrey Callen, MD, FACP, FAAD
Deputy Editor
Abena O Ofori, MD

INTRODUCTION

Lichen myxedematosus (LM, also called papular mucinosis) is a chronic idiopathic cutaneous mucinosis characterized by lichenoid papules, nodules, and/or plaques; mucin deposition and a variable degree of fibrosis in the dermis; and an absence of associated thyroid disease [1]. LM includes three clinicopathologic subsets (table 1) [1,2]:

Localized LM: A localized papular form of LM with a benign course and lack of systemic involvement.

Scleromyxedema: A diffuse/generalized papular and sclerodermoid form of LM associated with monoclonal gammopathy and systemic, potentially fatal, manifestations. (See "Scleromyxedema".)

Atypical or intermediate forms of LM: LM with atypical features or overlapping features of localized LM and scleromyxedema.

Localized LM is divided into four subtypes that are differentiated based upon clinical and histopathologic features (table 2 and picture 1A-E). The four subtypes are:

               

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Literature review current through: Jul 2017. | This topic last updated: Mar 23, 2017.
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